一名心脏移植痛风患者的别嘌醇静脉脱敏治疗
Intravenous desensitization to allopurinol in a heart transplant patient with gout.
作者信息
Schumacher Michael J, Copeland Jack G
机构信息
Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA.
出版信息
Ann Allergy Asthma Immunol. 2004 Mar;92(3):374-6. doi: 10.1016/S1081-1206(10)61577-3.
BACKGROUND
Oral desensitization with allopurinol presents a problem for patients with allopurinol hypersensitivity and gout that needs to be controlled rapidly. To our knowledge, only 1 case report of intravenous (i.v.) desensitization has been previously published.
OBJECTIVE
To present a case report of a patient with cutaneous reactions to allopurinol who underwent i.v. allopurinol desensitization.
METHODS
Intravenous infusion of allopurinol was performed using an escalating, 19-dose protocol.
RESULTS
No adverse reactions were precipitated by 2 i.v., escalating dose procedures, allowing continuation of effective treatment of the patient's hyperuricemia.
CONCLUSIONS
This case of safe and effective desensitization with allopurinol by the i.v. route should emphasize the need for a trial of this protocol in additional patients in whom rapid desensitization would be advantageous.
背景
对于需要迅速控制病情的别嘌醇过敏且患痛风的患者，口服别嘌醇进行脱敏治疗存在问题。据我们所知，此前仅发表过1例静脉内（i.v.）脱敏治疗的病例报告。
目的
报告1例对别嘌醇有皮肤反应的患者接受静脉内别嘌醇脱敏治疗的病例。
方法
采用逐步递增的19剂量方案进行别嘌醇静脉输注。
结果
2次静脉内递增剂量程序均未引发不良反应，从而得以继续有效治疗该患者的高尿酸血症。
结论
该例通过静脉途径使用别嘌醇进行安全有效的脱敏治疗，应强调有必要在其他可能从快速脱敏中获益的患者中试用此方案。
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