Morganroth J
University of Pennsylvania School of Medicine, Philadelphia.
Cardiol Clin. 1992 Aug;10(3):397-401.
Proarrhythmia is the provocation of a new arrhythmia or the exacerbation of a spontaneously occurring arrhythmia due to drug therapy. A drug's toxic effect may occur early after its initiation, and specific definitions have been offered to detect its presence. Primary and secondary forms of proarrhythmia as well as the type of early proarrhythmic events (fatal, serious, and nonserious) have been recognized. More recently, the concept of a late proarrhythmic event (enhanced arrhythmic death) has been defined using placebo-controlled trials. This late proarrhythmic response is extremely important in defining the benefit versus risk ratio that is the key to proper use of drug therapy.
致心律失常作用是指由于药物治疗引发新的心律失常或使自发发生的心律失常加重。药物的毒性作用可能在开始用药后早期出现，并且已经给出了检测其存在的具体定义。致心律失常作用的原发性和继发性形式以及早期致心律失常事件的类型（致命性、严重性和非严重性）已得到确认。最近，使用安慰剂对照试验定义了迟发性致心律失常事件（心律失常性死亡增加）的概念。这种迟发性致心律失常反应在确定获益与风险比方面极为重要，而获益与风险比是合理使用药物治疗的关键。
