Chulin A N, Rodionov I L, Ivanov V T
Laboratory of Peptide Chemistry, Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino, Moscow, Russia.
J Pept Res. 2004 Mar;63(3):235-40. doi: 10.1111/j.1399-3011.2004.00131.x.
Previously unknown 9-membered bridged dipeptides derived from l or d isomers of 1,3-diaminopropionic acids and l-glutamic acid were synthesized using aminoacyl incorporation reaction. Key intermediates containing internal pyroglutamyl moiety were prepared via side chain to backbone cyclization of related protected dipeptide derivatives of glutamic acid.
利用氨酰基掺入反应合成了以前未知的由1,3 - 二氨基丙酸的L型或D型异构体与L - 谷氨酸衍生的9元桥连二肽。含有内部焦谷氨酰基部分的关键中间体是通过谷氨酸相关保护二肽衍生物的侧链到主链环化制备的。
