Cruz M, Tusell J M, Grillo-Bosch D, Albericio F, Serratosa J, Rabanal F, Giralt E
Institut de Recerca Biomèdica de Barcelona, Parc Científic de Barcelona-UB, Josep Samitier 1, 08028 Barcelona, Spain.
J Pept Res. 2004 Mar;63(3):324-8. doi: 10.1111/j.1399-3011.2004.00156.x.
Single N-methyl amino acid-containing peptides related to the central hydrophobic region beta16-20 (Lys-Leu-Val-Phe-Phe) of the beta-amyloid protein are able to reduce the cytotoxicity of natural beta1-42 in PC12 cell cultures. N-methyl phenylalanine analogs yield statistically significant increments in cell viability (Student's t-test < 0.01%) and are nontoxic in the same assay. These promising results indicate that these peptide molecules could be a starting point for the development of potential therapeutic compounds for the treatment of Alzheimer's disease.
与β-淀粉样蛋白的中心疏水区域β16-20（赖氨酸-亮氨酸-缬氨酸-苯丙氨酸-苯丙氨酸）相关的含单个N-甲基氨基酸的肽能够降低PC12细胞培养物中天然β1-42的细胞毒性。N-甲基苯丙氨酸类似物在细胞活力方面产生具有统计学意义的增加（学生t检验<0.01%），并且在相同试验中无毒。这些有前景的结果表明，这些肽分子可能是开发用于治疗阿尔茨海默病的潜在治疗化合物的起点。
