Hummel M, Ziegler A G, Roth R
Diabetes Research Institute and 3rd Medical Department, Academic Hospital München-Schwabing, Munich, Germany.
Diabet Med. 2004 Apr;21(4):324-8. doi: 10.1111/j.1464-5491.2004.01142.x.
To determine anxiety in parents of children undergoing testing for islet autoantibodies.
Children of parents with Type 1 diabetes (T1DM) were tested at birth, age 9 months, 2 years and 5 years for islet autoantibodies. Families were informed about islet autoantibody status in the child after each visit. The psychological impact of islet autoantibody testing was assessed in parents before and after the 5 years visit. Anxiety was measured using a subscale of the State-Trait-Anxiety Inventory (STAI) and structured single-item questions. Four hundred and sixty-three parents were evaluated before blood drawing and 317 parents at notification of islet autoantibody status.
Before blood withdrawal, anxiety was increased in mothers and in particular in mothers of islet autoantibody-positive offspring compared with a normative control group. At notification of islet antibody status, anxiety significantly decreased in parents of islet autoantibody-negative offspring, and increased in parents of islet autoantibody-positive offspring. Blood withdrawal was considered a burden for parents and offspring (15% and 48%, respectively). Most parents from islet autoantibody-negative and -positive offspring wished to know the diabetes risk of their child (95% and 100%, respectively) and were glad to be informed about their child's islet antibody status (97% and 87%).
Overall, islet autoantibody testing in early childhood reduces anxiety in T1DM families. The increased anxiety associated with islet autoantibody-positive status suggests, however, that testing should be performed in centres which can provide accurate risk information and counselling if required.
确定接受胰岛自身抗体检测儿童的父母的焦虑状况。
1型糖尿病（T1DM）患儿的父母在孩子出生时、9个月、2岁和5岁时接受胰岛自身抗体检测。每次就诊后，向家长告知孩子的胰岛自身抗体状态。在5年随访前后，评估胰岛自身抗体检测对家长的心理影响。使用状态-特质焦虑量表（STAI）的一个子量表和结构化单项问题来测量焦虑。463名家长在采血前接受评估，317名家长在得知胰岛自身抗体状态时接受评估。
与正常对照组相比，采血前母亲的焦虑增加，尤其是胰岛自身抗体呈阳性后代的母亲。在得知胰岛抗体状态时，胰岛自身抗体呈阴性后代的父母焦虑显著降低，而胰岛自身抗体呈阳性后代的父母焦虑增加。采血被认为是家长和孩子的负担（分别为15%和48%）。大多数胰岛自身抗体呈阴性和阳性后代的家长希望了解孩子患糖尿病的风险（分别为95%和100%），并且很高兴得知孩子的胰岛抗体状态（分别为97%和87%）。
总体而言，幼儿期进行胰岛自身抗体检测可减轻T1DM家庭的焦虑。然而，与胰岛自身抗体呈阳性状态相关的焦虑增加表明，检测应在能够提供准确风险信息并在需要时提供咨询的中心进行。
