Heldgaard P E, Olivarius N de F, Hindsberger C, Henriksen J E
Ørum Health Centre, Tjele, Denmark.
Diabet Med. 2004 Apr;21(4):363-70. doi: 10.1111/j.1464-5491.2004.01231.x.
To compare subjects with impaired glucose tolerance and impaired fasting glucose in relation to risk factors for developing cardiovascular disease.
A total of 1374 patients (678 female, 696 male) listed with a general practice clinic in Denmark were given an oral glucose tolerance test, a physical examination, and a self-administered questionnaire. Risk factors for cardiovascular disease were assessed for 90 participants (48 female, 42 male) with impaired glucose tolerance (including 12 subjects (1 female and 11 male), who also fulfilled criteria for impaired fasting glycaemia) and 51 subjects (20 female, 31 male) with impaired fasting glycaemia (World Health Organization 1999 criteria).
There were no statistical differences with regard to known risk factors for cardiovascular disease between participants with isolated impaired fasting glycaemia and those with impaired glucose tolerance.
We found noticeable similarities in the cardiovascular risk factor profile in subjects with impaired fasting glycaemia and in subjects with impaired glucose tolerance in our population. When planning screening initiatives, it seems relevant to take into account people with impaired fasting glycaemia as well as those with impaired glucose tolerance.
比较糖耐量受损和空腹血糖受损受试者与心血管疾病发生风险因素的关系。
丹麦一家普通诊所登记的1374例患者(678例女性,696例男性)接受了口服葡萄糖耐量试验、体格检查和自行填写的问卷调查。对90例糖耐量受损参与者(48例女性,42例男性)(包括12例同时符合空腹血糖受损标准的受试者(1例女性和11例男性))和51例空腹血糖受损受试者(20例女性,3例男性)(采用世界卫生组织1999年标准)评估心血管疾病风险因素。
单纯空腹血糖受损参与者与糖耐量受损参与者在已知心血管疾病风险因素方面无统计学差异。
我们发现,在我们的研究人群中,空腹血糖受损受试者和糖耐量受损受试者的心血管风险因素谱存在明显相似之处。在规划筛查项目时,似乎有必要将空腹血糖受损者和糖耐量受损者都考虑在内。