Gokce G, Bagcivan I, Kilicarslan H, Yildirim S, Gultekin Y E, Sarioglu Y
Department of Urology, Cumhuriyet University, Sivas, Turkey.
BJU Int. 2004 Apr;93(6):859-62. doi: 10.1111/j.1464-410X.2003.04728.x.
To clarify the pharmacological effects of adrenomedullin, a potent vasodilator and hypotensive peptide isolated from human phaeochromocytoma cells, on corpus cavernosal smooth muscle in vitro, as the intracavernosal injection of adrenomedullin induces penile erection in the anaesthetized cat.
The effects of adrenomedullin were investigated in isolated muscle strips from New Zealand rabbit corpus cavernosum smooth muscle pre-contracted with phenylephrine alone, in the presence of indomethacin (cyclooxygenase inhibitor), Nomega-nitro l-arginine methyl ester (L-NAME, a nitric oxide synthase inhibitor), and K+-channel blockers.
Adrenomedullin caused relaxation of isolated pre-contracted rabbit corpus cavernosum strips in a concentration-dependent manner. The response of corpus cavernosum was unaffected L-NAME, indomethacin and K+-channel blockers.
The relaxation exerted by adrenomedullin in rabbit corporal tissue may arise from the effect of the drug on its specific receptors and/or calcitonin gene-related peptide-1 receptors. The relaxant effect of adrenomedullin might lead to novel clinical applications for erectile dysfunction.
肾上腺髓质素是一种从人嗜铬细胞瘤细胞中分离出的强效血管舒张剂和降压肽，由于在麻醉猫体内海绵体内注射肾上腺髓质素可诱导阴茎勃起，本研究旨在阐明其对体外海绵体平滑肌的药理作用。
在单独用去氧肾上腺素预收缩的新西兰兔海绵体平滑肌分离肌条中，研究肾上腺髓质素在存在吲哚美辛（环氧化酶抑制剂）、N-硝基-L-精氨酸甲酯（L-NAME，一种一氧化氮合酶抑制剂）和钾通道阻滞剂的情况下的作用。
肾上腺髓质素以浓度依赖性方式使分离的预收缩兔海绵体条松弛。海绵体的反应不受L-NAME、吲哚美辛和钾通道阻滞剂的影响。
肾上腺髓质素在兔海绵体组织中产生的松弛作用可能源于该药物对其特异性受体和/或降钙素基因相关肽-1受体的作用。肾上腺髓质素的松弛作用可能会为勃起功能障碍带来新的临床应用。
