Matsuoka Naoki, Kohriyama Tatsuo, Ochi Kazuhide, Nishitani Michie, Sueda Yoshimasa, Mimori Yasuyo, Nakamura Shigenobu, Matsumoto Masayasu
Department of Clinical Neuroscience and Therapeutics, Division of Integrated Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Hiroshima, 734-8551, Japan.
J Neurol Sci. 2004 Apr 15;219(1-2):15-21. doi: 10.1016/j.jns.2003.11.011.
Several studies have demonstrated abnormal MRI findings in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), especially hypertrophy and abnormal enhancement of spinal nerve roots, but there have been few reports on ultrasonographic findings of spinal nerve roots in CIDP. To determine whether ultrasonography (US) enables detection of hypertrophy of the cervical nerve roots, how frequently hypertrophy occurs in CIDP, and whether US findings correlate with any clinical and laboratory features, US of cervical nerve roots was performed using a 7.5-MHz linear-array transducer in 13 CIDP patients and 35 control subjects. A coronal oblique plane with a transducer placed on the lateral side of the neck was used to visualize the cervical nerve roots just after their point of exit from the cervical foramina, and their diameters were measured. US demonstrated hypertrophy of the cervical nerve roots in 9 (69%) of the 13 CIDP patients as compared with findings in control subjects. The degree of hypertrophy was significantly associated with the level of CSF protein (chi2=5.8, p<0.05, logistic simple regression analysis) but not with other clinical features. US is considered to be a useful method for evaluating cervical nerve root hypertrophy, which is frequently seen in patients with CIDP, particularly in patients with elevated level of CSF protein.
多项研究已证实慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）存在MRI异常表现，尤其是脊神经根增粗和异常强化，但关于CIDP患者脊神经根超声表现的报道较少。为了确定超声（US）能否检测出颈神经根增粗、CIDP患者中增粗的发生频率以及US表现是否与任何临床和实验室特征相关，我们使用7.5MHz线阵探头对13例CIDP患者和35例对照者进行了颈神经根超声检查。将探头置于颈部外侧，采用冠状斜平面来观察颈神经根刚从颈椎椎间孔穿出后的情况，并测量其直径。与对照者相比，13例CIDP患者中有9例（69%）经US显示颈神经根增粗。增粗程度与脑脊液蛋白水平显著相关（χ2 = 5.8，p < 0.05，逻辑简单回归分析），但与其他临床特征无关。超声被认为是评估颈神经根增粗的一种有用方法，颈神经根增粗在CIDP患者中常见，尤其是脑脊液蛋白水平升高的患者。
