Jung Mankil, Lee Kyunghoon, Jung Hochul, Kendrick Howard, Yardley Vanessa, Croft Simon L
Department of Chemistry, Yonsei University, Seoul 120-749, South Korea.
Bioorg Med Chem Lett. 2004 Apr 19;14(8):2001-3. doi: 10.1016/j.bmcl.2003.12.104.
(+)-Deoxoartemisitene and its C-11, 13 derivatives were synthesized from artemisinic acid via a short and regiospecific process and several derivatives show 10-20 times more in vitro antimalarial activities against Plasmodium falciparum than artemisinin.
（+）-脱氧青蒿烯及其C-11、13衍生物通过简短且区域特异性的过程从青蒿酸合成，几种衍生物对恶性疟原虫的体外抗疟活性比青蒿素高10至20倍。
