Luo Jian, Shi Riyi
Department of Basic Medical Sciences, Institute for Applied Neurology, Center for Paralysis Research, Purdue University, West Lafayette, IN 47907, USA.
Neurosci Lett. 2004 Apr 15;359(3):167-70. doi: 10.1016/j.neulet.2004.02.027.
Spinal cord injury (SCI) results in rapid and significant oxidative stress. We have previously demonstrated that polyethylene glycol (PEG) repairs neuronal membrane and inhibits lipid peroxidation in an in vitro model of SCI. In this study we tested the effects of PEG on oxidative stress in guinea pigs after SCI. Oxidative stress was assessed by lipid peroxidation, protein carbonyl and glutathione content. A compression injury of spinal cord at T10-11 induced a rapid and diffusive oxidative stress. Administration of PEG immediately after injury resulted in a marked decrease in oxidative stress both at the injury site and in its adjacent segments. These results, along with our previous findings, suggest that an early application of PEG can effectively suppress oxidative stress after SCI in vivo.
脊髓损伤（SCI）会导致迅速且显著的氧化应激。我们之前已经证明，在脊髓损伤的体外模型中，聚乙二醇（PEG）可修复神经元膜并抑制脂质过氧化。在本研究中，我们测试了PEG对脊髓损伤后豚鼠氧化应激的影响。通过脂质过氧化、蛋白质羰基和谷胱甘肽含量评估氧化应激。T10 - 11节段的脊髓压迫性损伤会引发迅速且弥漫性的氧化应激。损伤后立即给予PEG可使损伤部位及其相邻节段的氧化应激显著降低。这些结果，连同我们之前的发现，表明早期应用PEG可有效抑制体内脊髓损伤后的氧化应激。
