Perna Giampaolo, Casolari Alessia, Bussi Riccardo, Cucchi Michele, Arancio Cinzia, Bellodi Laura
Department of Neuropsychiatric Sciences, Istituto Scientifico H. San Raffaele, Vita-Salute University, 20 via Stamira d'Ancona, 20127 Milan, Italy.
Psychiatry Res. 2004 Mar 15;125(3):277-83. doi: 10.1016/j.psychres.2003.12.017.
Patients with panic disorder (PD) are hyperreactive to carbon dioxide (CO(2)), but the specificity of this characteristic to PD is controversial. Anxiety and phobic symptomatology are common to both panic and eating disorders (ED). To investigate the specificity of CO(2) hyperreactivity to PD, the responses to inhalation of a 35% CO(2) and 65% oxygen (O(2)) gas mixture were assessed. Reactions to 35% CO(2) challenge were compared among three groups of age- and sex-matched subjects: 14 patients with ED, 14 patients with PD, and 14 healthy controls (HC). A double-blind, randomized, crossover design was used. Only patients with PD showed a strong reaction to 35% CO(2), while patients with ED and HC did not react significantly. The results support the specificity of CO(2) hyperreactivity to PD.
惊恐障碍（PD）患者对二氧化碳（CO₂）反应过度，但这一特征对PD的特异性存在争议。焦虑和恐惧症状在惊恐障碍和进食障碍（ED）中都很常见。为了研究CO₂反应过度对PD的特异性，评估了吸入35% CO₂和65%氧气（O₂）混合气体的反应。在三组年龄和性别匹配的受试者中比较了对35% CO₂激发试验的反应：14例进食障碍患者、14例惊恐障碍患者和14名健康对照者（HC）。采用双盲、随机、交叉设计。只有惊恐障碍患者对35% CO₂表现出强烈反应，而进食障碍患者和健康对照者没有明显反应。结果支持CO₂反应过度对PD的特异性。
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