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硫化氢：辣椒素敏感的初级传入神经元的内源性刺激物？

Hydrogen sulphide: an endogenous stimulant of capsaicin-sensitive primary afferent neurons?

作者信息

Chahl L A

机构信息

School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia.

出版信息

Br J Pharmacol. 2004 May;142(1):1-2. doi: 10.1038/sj.bjp.0705765. Epub 2004 Mar 29.

DOI:10.1038/sj.bjp.0705765
PMID:15051628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1574936/
Abstract

Hydrogen sulphide (H(2)S) is a gas best known for its rotten egg smell. The toxic effects of high concentrations of H(2)S have been extensively investigated. It is known that H(2)S is generated in mammalian systems, but little is known of its effects in physiological concentrations. In the present issue of this journal, Patacchini et al. present evidence that H(2)S stimulates capsaicin-sensitive primary afferent neurons to release tachykinins in the rat urinary bladder. The possible significance of this finding is discussed in this commentary.

摘要

硫化氢（H₂S）是一种因其臭鸡蛋气味而广为人知的气体。高浓度硫化氢的毒性作用已得到广泛研究。已知硫化氢在哺乳动物系统中会产生，但对其在生理浓度下的影响却知之甚少。在本期杂志中，帕塔基尼等人提供了证据表明，硫化氢会刺激辣椒素敏感的初级传入神经元，使其在大鼠膀胱中释放速激肽。本评论将讨论这一发现的可能意义。

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Hydrogen sulphide: an endogenous stimulant of capsaicin-sensitive primary afferent neurons?硫化氢：辣椒素敏感的初级传入神经元的内源性刺激物？
Br J Pharmacol. 2004 May;142(1):1-2. doi: 10.1038/sj.bjp.0705765. Epub 2004 Mar 29.
2
Hydrogen sulfide (H2S) stimulates capsaicin-sensitive primary afferent neurons in the rat urinary bladder.硫化氢（H₂S）刺激大鼠膀胱中对辣椒素敏感的初级传入神经元。
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Capsaicin pretreatment modifies hydrogen sulphide-induced pulmonary injury in rats.辣椒素预处理可改变硫化氢诱导的大鼠肺损伤。
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本文引用的文献

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Novel neural modulators.新型神经调节剂。
Annu Rev Neurosci. 2003;26:105-31. doi: 10.1146/annurev.neuro.26.041002.131047.
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Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?两人成伴，三人不欢：硫化氢能成为第三种内源性气体递质吗？
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Tachykinin antagonists and capsaicin-induced contraction of the rat isolated urinary bladder: evidence for tachykinin-mediated cotransmission.速激肽拮抗剂与辣椒素诱导的大鼠离体膀胱收缩：速激肽介导的共传递证据
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