Routt Sheri M, Bankaitis Vytas A
Department of Cell and Developmental Biology, School of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599-7090, USA.
Biochem Cell Biol. 2004 Feb;82(1):254-62. doi: 10.1139/o03-089.
Phosphatidylinositol/phosphatidylcholine transfer proteins (PITPs) are ubiquitous and highly conserved proteins that are believed to regulate lipid-mediated signaling events. Their ubiquity and conservation notwithstanding, PITPs remain remarkably uninvestigated. Little is known about the coupling of specific PITPs to explicit cellular functions or the mechanisms by which PITPs interface with appropriate cellular functions. The available information indicates a role for these proteins in regulating the interface between lipid metabolism and membrane trafficking in yeast, signaling in plant development, the trafficking of specialized luminal cargo in mammalian enterocytes, and neurological function in mammals. Herein, we review recent advances in PITP biology and discuss as yet unresolved issues in this field.
磷脂酰肌醇/磷脂酰胆碱转移蛋白（PITPs）是普遍存在且高度保守的蛋白质，被认为可调节脂质介导的信号转导事件。尽管它们具有普遍性和保守性，但PITPs仍未得到充分研究。对于特定PITPs与明确的细胞功能之间的关联，或者PITPs与适当细胞功能相互作用的机制，我们知之甚少。现有信息表明，这些蛋白质在调节酵母中脂质代谢与膜运输之间的界面、植物发育中的信号传导、哺乳动物肠上皮细胞中特殊腔内货物的运输以及哺乳动物的神经功能方面发挥作用。在此，我们综述了PITP生物学的最新进展，并讨论了该领域尚未解决的问题。
