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[机体终末状态下血液-组织系统代谢过程的时空变化]

[Spatio-temporal changes in the metabolic processes in the blood-tissue system in the terminal states of the organism].

作者信息

Kozlova E K, Fomina U A, Moroz V V, Bogushevich M S, Chernysh A M

出版信息

Patol Fiziol Eksp Ter. 2004 Jan-Mar(1):20-2.

Abstract

The role of synergism in diffusion of oxygen from erythrocyte into interstitial liquid and water filtration through the capillary wall was studied on the model using the following parameters: hydrostatic pressure on arterial and venous ends of the capillary (Pa and Pb), oncotic blood and tissue pressure (Pob and Pot), pore radius in the capillary (r), the number of pores in the capillary (n) per m2, amount of the liquid released from the capillary (q(x)), gas diffusion coefficient (D), time of erythrocyte movement in the capillary (T), speed of oxygen consumption (V), maximal distance with adequate V (Xmax), characteristic time of diffusion (Topt). It is shown that diffuse and convective components of the metabolic process have their own contribution and in changed conditions they redistribute. In increased number and diameter of hydravlic pores the greatest role in tissue saturation with oxygen belongs to convective metabolism, but in this situation tissues contain areas lacking oxygen.

摘要

在该模型上,利用以下参数研究了协同作用在氧气从红细胞扩散到组织液以及水通过毛细血管壁滤过过程中的作用:毛细血管动脉端和静脉端的静水压力(Pa和Pb)、血液胶体渗透压和组织渗透压(Pob和Pot)、毛细血管中的孔隙半径(r)、每平方米毛细血管中的孔隙数量(n)、从毛细血管释放的液体量(q(x))、气体扩散系数(D)、红细胞在毛细血管中的移动时间(T)、氧气消耗速度(V)、在足够的V下的最大距离(Xmax)、扩散特征时间(Topt)。结果表明,代谢过程的扩散和对流成分都有各自的贡献,并且在条件变化时它们会重新分布。在液压孔隙数量和直径增加的情况下,对组织氧气饱和起最大作用的是对流代谢,但在这种情况下组织中存在缺氧区域。

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