Bulut Gulcin, Zekioglu Osman, Eronat Cemal, Bulut Hakan
Department of Paediatric Dentistry, Faculty of Dentistry, Ege University, 35100 Bornova-Izmir, Turkey.
J Dent. 2004 May;32(4):309-14. doi: 10.1016/j.jdent.2004.01.004.
The aim of this study was to investigate histopathologically after 1 week and 1 month the effect of Carisolv on exposed human pulp after a contact period of 10 min in comparison to sterile saline solution.
Class V cavities were prepared in 40 human first premolars, and the pulp chambers were perforated. The pulp tissue was either exposed to Carisolv or sterile saline solution for 10 min, covered with Teflon and restored with compomer filling material. After observation periods of 1 week and 1 month, the teeth were extracted and examined by light microscopy.
Histological evaluation revealed similar pulpal response which consisted of a slight inflammation in both groups after 1 week. The only difference was localized haemorrhage in controls while no haemorrhage was observed in the test group which may show the haemostatic effect of Carisolv. After 1 month the test teeth displayed a very mild inflammation adjacent to the perforation area while haemorrhage disappeared in the controls. In general, pulps showed structural integrity in both groups. Statistical analysis showed no difference between the test and the control groups in both test periods.
The results suggest that Carisolv is biocompatible with human pulp tissue and may have a haemostatic effect.
本研究旨在与无菌生理盐水溶液相比，在接触10分钟后，对暴露的人牙髓组织进行1周和1个月的组织病理学研究，观察Carisolv的作用效果。
在40颗人类第一前磨牙上制备V类洞，穿通髓腔。将牙髓组织分别暴露于Carisolv或无菌生理盐水溶液中10分钟，覆盖聚四氟乙烯，并用复合树脂充填材料修复。在观察1周和1个月后，拔除牙齿并进行光学显微镜检查。
组织学评估显示，两组在1周后牙髓反应相似，均有轻微炎症。唯一的区别是对照组出现局部出血，而试验组未观察到出血，这可能表明Carisolv具有止血作用。1个月后，试验组牙齿在穿孔区域附近显示非常轻微的炎症，而对照组出血消失。总体而言，两组牙髓均显示结构完整。统计分析表明，在两个试验期内，试验组和对照组之间没有差异。
结果表明，Carisolv与人牙髓组织具有生物相容性，可能具有止血作用。
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