Kirn-Safran Catherine B, Gomes Ronald R, Brown Anissa J, Carson Daniel D
Department of Biological Sciences, University of Delaware, Newark, Delaware, USA.
Birth Defects Res C Embryo Today. 2004 Mar;72(1):69-88. doi: 10.1002/bdrc.20005.
Heparan sulfate proteoglycans are abundantly expressed in the pericellular matrix of both developing and mature cartilage. Increasing evidence indicates that the action of numerous chondroregulatory molecules depends on these proteoglycans. This review summarizes the current understanding of the interactions of heparan sulfate chains of cartilage proteoglycans with both soluble and nonsoluble ligands during the process of chondrogenesis. In addition, the consequences of mutating genes encoding heparan sulfate biosynthetic enzymes or heparan sulfate proteoglycan core proteins on cartilage development are discussed.
硫酸乙酰肝素蛋白聚糖在发育中和成熟的软骨细胞周围基质中大量表达。越来越多的证据表明，许多软骨调节分子的作用都依赖于这些蛋白聚糖。这篇综述总结了目前对软骨蛋白聚糖硫酸乙酰肝素链在软骨形成过程中与可溶性和不可溶性配体相互作用的理解。此外，还讨论了编码硫酸乙酰肝素生物合成酶或硫酸乙酰肝素蛋白聚糖核心蛋白的基因突变对软骨发育的影响。
