Vasilca Venera, Vasilca A, Munteanu Dorina, Constantinescu Daniela, Livideanu Cristina, Tepeluş Maria, Zugun F, Carasevici E
Gr. T. Popa University of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Iaşi, Romania.
Roum Arch Microbiol Immunol. 2002 Oct-Dec;61(4):259-65.
The aim of the study was to identify HLA class I types associated with susceptibility to psoriasis among population of Northeast region of Romania.
27 psoriatic patients and 89 controls were typed serologically for HLA-A and HLA-B lymphocyte expression using CDC-NIH (complement dependent-cytotoxicity--National Institute of Health) method. The Terasaki plates used for HLA class I typing were prepared in our laboratory using antisera of known specificities.
psoriatic patients in the group of study frequently express HLA-B57 phenotype. The relative risk induced by this phenotype was highly statistically significant (p = 0.0016) while HLA-B13 was not associated with a significant risk for developing psoriasis in patients under study compared with controls (p = 0.48). Also, HLA-B27 (p = 0.96) and HLA-B44 (p = 0.99), reported by others to be associated with late psoriasis, do not meet (a particular) disease susceptibility between psoriatic patients under investigation.
