Stacy Donnie R, Lu Bo, Hallahan Dennis E
Department of Radiation Oncology, Vanderbilt University Medical Center, 1301 22nd Avenue South, B-902 The Vanderbilt Clinic, Nashville, TN 37232-5671, USA.
Expert Rev Anticancer Ther. 2004 Apr;4(2):283-8. doi: 10.1586/14737140.4.2.283.
A primary limiting factor for cancer treatment is normal tissue toxicity. Targeted cancer treatment can potentially maximize cancer cure and minimize normal tissue toxicity. Physical energy can be used to activate inert oncologic drugs. X-rays have an advantage over other forms of physical energy because tissue penetration and precise localization can be achieved. Radiation can be used to control drug delivery through radiation-inducible gene therapy. Radiation-guided drug delivery systems involve the targeting of immunoconjugates to radiation-inducible neoantigens induced by irradiation of neoplasms. Magnetic fields can compliment these technologies by drawing magnetic particles containing oncologic drugs toward an externally applied magnetic field. The field of targeted drug delivery by use of external radiation fields will ultimately bring new delivery systems into clinical trials. This review highlights radiation-guided cancer drug delivery systems, at preclinical and clinical stages of development, to tumors and tumor blood vessels.
癌症治疗的一个主要限制因素是正常组织毒性。靶向癌症治疗有可能使癌症治愈率最大化，并将正常组织毒性降至最低。物理能量可用于激活惰性肿瘤药物。X射线比其他形式的物理能量具有优势，因为它可以实现组织穿透和精确定位。辐射可通过辐射诱导基因疗法用于控制药物递送。辐射引导药物递送系统涉及将免疫缀合物靶向由肿瘤照射诱导的辐射诱导新抗原。磁场可以通过将含有肿瘤药物的磁性颗粒吸引到外部施加的磁场来补充这些技术。利用外部辐射场进行靶向药物递送的领域最终将使新的递送系统进入临床试验。本综述重点介绍了处于临床前和临床开发阶段的、针对肿瘤和肿瘤血管的辐射引导癌症药物递送系统。
