Preuss H G, Bagchi D, Bagchi M, Rao C V S, Dey D K, Satyanarayana S
Department of Physiology and Biophysics, Georgetown University Medical Center, Georgetown, Washington, DC 20057, USA.
Diabetes Obes Metab. 2004 May;6(3):171-80. doi: 10.1111/j.1462-8902.2004.00328.x.
The efficacy of optimal doses of highly bioavailable (-)-hydroxycitric acid (HCA-SX) alone and in combination with niacin-bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites. HCA-SX has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. NBC has demonstrated its ability to maintain healthy insulin levels, while GSE has been shown to regulate weight loss and blood sugar levels.
A randomized, double-blind, placebo-controlled human study was conducted in Elluru, India for 8 weeks in 60 moderately obese subjects (ages 21-50, BMI >26 kg/m(2)). Subjects were randomly divided into three groups. Group A was administered HCA-SX 4667 mg, group B was administered a combination of HCA-SX 4667 mg, NBC 4 mg and GSE 400 mg, while group C was given placebo daily in three equally divided doses 30-60 min before meals. All subjects received a 2000 kcal diet/day and participated in supervised walking.
At the end of 8 weeks, body weight and BMI decreased by 5-6% in both groups A and B. Food intake, total cholesterol, low-density lipoproteins, triglycerides and serum leptin levels were significantly reduced in both groups, while high-density lipoprotein levels and excretion of urinary fat metabolites increased in both groups. A marginal or non-significant effect was observed in all parameters in group C.
The present study shows that optimal doses of HCA-SX and, to a greater degree, the combination of HCA-SX, NBC and GSE can serve as an effective and safe weight-loss formula that can facilitate a reduction in excess body weight and BMI, while promoting healthy blood lipid levels.
通过监测体重、体重指数（BMI）、食欲、血脂谱、血清瘦素和尿脂肪代谢产物排泄的变化，评估最佳剂量的高生物利用度（-）-羟基柠檬酸（HCA-SX）单独使用以及与烟酸铬（NBC）和标准化匙羹藤提取物（GSE）联合使用对中度肥胖受试者体重减轻的效果。HCA-SX已被证明可降低食欲、抑制脂肪合成并减轻体重，而不会刺激中枢神经系统。NBC已证明其能够维持健康的胰岛素水平，而GSE已被证明可调节体重减轻和血糖水平。
在印度埃卢鲁对60名中度肥胖受试者（年龄21-50岁，BMI>26 kg/m²）进行了一项为期8周的随机、双盲、安慰剂对照人体研究。受试者被随机分为三组。A组服用4667毫克HCA-SX，B组服用4667毫克HCA-SX、4毫克NBC和400毫克GSE的组合，而C组在饭前30-60分钟每天分三次等量服用安慰剂。所有受试者每天摄入2000千卡的饮食，并参加有监督的步行活动。
8周结束时，A组和B组的体重和BMI均下降了5-6%。两组的食物摄入量、总胆固醇、低密度脂蛋白、甘油三酯和血清瘦素水平均显著降低，而两组的高密度脂蛋白水平和尿脂肪代谢产物排泄量增加。C组在所有参数上均观察到轻微或无显著影响。
本研究表明，最佳剂量的HCA-SX，以及在更大程度上，HCA-SX、NBC和GSE的组合可作为一种有效且安全的减肥配方，有助于减轻多余体重和BMI，同时促进健康的血脂水平。
