Kim Kyoung-Jin, Lee Hae-Woong, Lee Mi-Woo, Choi Jee-Ho, Moon Kee-Chan, Koh Jai-Kyoung
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, Korea.
Dermatol Surg. 2004 Apr;30(4 Pt 1):545-7. doi: 10.1111/j.1524-4725.2004.30174.x.
Artecoll is now being widely used as an injectable aesthetic microimplant for the treatment of wrinkles because of its long-lasting cosmetic effects and the rarity of late complications, including foreign body granulomas. Recently, however, several cases of Artecoll-induced granulomas on the face have been reported, especially in patients receiving overly superficial or overly correcting implants.
A 50-year-old Korean woman who had been treated with Artecoll for the correction of the neck wrinkles presented 4 years later with an extensive Artecoll-induced foreign body granuloma along the injection sites in the neck. After three intralesional injections of triamcinolone acetonide, the lesions had almost disappeared.
To our knowledge, this case is the first report of an extensive Artecoll-induced granuloma on the neck. Our findings suggest that Artecoll not be used as implant material in thin and constantly movable skin, such as that of the neck.
由于爱贝芙（Artecoll）具有持久的美容效果且晚期并发症（包括异物肉芽肿）罕见，它目前被广泛用作可注射的美容微植入物来治疗皱纹。然而，最近有几例面部爱贝芙诱发肉芽肿的病例被报道，尤其是在接受植入过浅或矫正过度的患者中。
一名50岁的韩国女性曾接受爱贝芙治疗颈部皱纹，4年后在颈部注射部位出现广泛的爱贝芙诱发异物肉芽肿。经三次曲安奈德皮损内注射后，病变几乎消失。
据我们所知，该病例是颈部广泛的爱贝芙诱发肉芽肿的首例报告。我们的研究结果表明，爱贝芙不应作为颈部等薄且经常活动的皮肤的植入材料。
