Elkins Irene J, McGue Matt, Malone Steve, Iacono William G
Department of Psychiatry, University of Minnesota, Minneapolis, 55455, USA.
Am J Psychiatry. 2004 Apr;161(4):670-6. doi: 10.1176/appi.ajp.161.4.670.
The relationship of parental alcohol or drug diagnosis to offspring personality was examined in a population-based sample of 17-year-old twins (568 girls and 479 boys) participating in the Minnesota Twin Family Study. Whether offspring personality characteristics 1) are specific to the type of substance use disorder in parents (alcohol versus drug) and 2) are found in high-risk offspring without substance use disorders as well as in offspring with substance use disorders was investigated.
Personality was assessed with the Multidimensional Personality Questionnaire; substance use disorders were assessed in person through diagnostic interviews.
In both male and female offspring, parental history of alcohol dependence was associated with greater negative emotionality, aggression, stress reaction, and alienation but lower well-being; parental history of drug disorders was associated with lower constraint, control, harm avoidance, and traditionalism but higher social potency. Excluding offspring with a substance use disorder had virtually no effect on the statistical significance of these findings.
In contrast to findings in some adult samples, personality characteristics associated with a family history of substance use disorders are found even in adolescent offspring who have not yet developed these disorders themselves, suggesting that personality might be one indicator of familial risk for substance use disorders during this developmental stage. Personality profiles of offspring of parents with substance use disorders also show some diagnostic specificity, with constraint associated with parental drug abuse and negative emotionality with parental alcoholism.
在参与明尼苏达双胞胎家庭研究的17岁双胞胎(568名女孩和479名男孩)的基于人群的样本中,研究父母的酒精或药物诊断与后代人格之间的关系。研究后代的人格特征是否:1)特定于父母物质使用障碍的类型(酒精与药物);2)在没有物质使用障碍的高危后代以及有物质使用障碍的后代中都能发现。
使用多维人格问卷评估人格;通过诊断访谈亲自评估物质使用障碍。
在男性和女性后代中,父母的酒精依赖史与更高的负面情绪、攻击性、应激反应和疏离感相关,但幸福感较低;父母的药物障碍史与较低的约束性、控制性、避免伤害和传统主义相关,但社交效能较高。排除有物质使用障碍的后代对这些发现的统计学显著性几乎没有影响。
与一些成人样本的研究结果相反,即使在尚未自身发展出这些障碍的青少年后代中,也发现了与物质使用障碍家族史相关的人格特征,这表明人格可能是这个发育阶段物质使用障碍家族风险的一个指标。有物质使用障碍的父母的后代的人格特征也显示出一些诊断特异性,约束性与父母药物滥用相关,负面情绪与父母酗酒相关。