Merikangas K R, Dierker L C, Szatmari P
Yale University School of Medicine, New Haven, CT 06510, USA.
J Child Psychol Psychiatry. 1998 Jul;39(5):711-20.
This paper reports the results of a high-risk study of children under age 18 of parents who served as probands in a family study of comorbidity of substance abuse and anxiety disorders. There was a strong degree of specificity of familial aggregation of both the anxiety disorders and substance disorders. Rates of conduct disorder and depression were elevated among offspring of all affected parents. Inclusion of co-parent disorders in the evaluation of familial transmission in the present study strengthened the findings regarding the specificity of transmission of the anxiety disorders and the links between both parental substance abuse and antisocial personality with child conduct disorder.
本文报告了一项针对18岁以下儿童的高风险研究结果，这些儿童的父母是药物滥用与焦虑症共病家庭研究中的先证者。焦虑症和物质障碍在家族聚集方面具有很强的特异性。在所有受影响父母的后代中，品行障碍和抑郁症的发生率都有所升高。在本研究中，将共同父母的障碍纳入家族传播评估，强化了关于焦虑症传播特异性以及父母药物滥用和反社会人格与儿童品行障碍之间联系的研究结果。
