使用4-(4,6-二甲氧基-1,3,5-三嗪-2-基)-4-甲基吗啉鎓氯化物（DMT-MM）制备Weinreb酰胺。

Preparation of Weinreb amides using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM).

作者信息

Hioki Kazuhito, Kobayashi Hiroko, Ohkihara Rumi, Tani Shohei, Kunishima Munetaka

机构信息

Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2004 Apr;52(4):470-2. doi: 10.1248/cpb.52.470.

DOI:10.1248/cpb.52.470

PMID:15056969

Abstract

Weinreb amides were successfully prepared from the corresponding carboxylic acids using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) in the solvents, methanol, isopropyl alcohol, and acetonitrile, which can solubilize DMT-MM. A variety of carboxylic acids were converted to the corresponding Weinreb amides in excellent yields by simply mixing with DMT-MM and N,O-dimethylhydroxylamine hydrochloride.

摘要

使用4-(4,6-二甲氧基-1,3,5-三嗪-2-基)-4-甲基吗啉鎓氯化物（DMT-MM），在可溶解DMT-MM的甲醇、异丙醇和乙腈等溶剂中，由相应的羧酸成功制备了Weinreb酰胺。通过简单地将多种羧酸与DMT-MM和N,O-二甲基羟胺盐酸盐混合，它们以优异的产率转化为相应的Weinreb酰胺。