Hioki Kazuhito, Kobayashi Hiroko, Ohkihara Rumi, Tani Shohei, Kunishima Munetaka
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University, Japan.
Chem Pharm Bull (Tokyo). 2004 Apr;52(4):470-2. doi: 10.1248/cpb.52.470.
Weinreb amides were successfully prepared from the corresponding carboxylic acids using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) in the solvents, methanol, isopropyl alcohol, and acetonitrile, which can solubilize DMT-MM. A variety of carboxylic acids were converted to the corresponding Weinreb amides in excellent yields by simply mixing with DMT-MM and N,O-dimethylhydroxylamine hydrochloride.
使用4-(4,6-二甲氧基-1,3,5-三嗪-2-基)-4-甲基吗啉鎓氯化物（DMT-MM），在可溶解DMT-MM的甲醇、异丙醇和乙腈等溶剂中，由相应的羧酸成功制备了Weinreb酰胺。通过简单地将多种羧酸与DMT-MM和N,O-二甲基羟胺盐酸盐混合，它们以优异的产率转化为相应的Weinreb酰胺。
