通过咽骨组织形态计量学研究生长激素对虹鳟（Oncorhynchus mykiss）骨形成和骨吸收的影响。
Effects of growth hormones on bone formation and resorption in rainbow trout (Oncorhynchus mykiss), as examined by histomorphometry of the pharyngeal bone.
作者信息
Takagi Y, Moriyama S, Hirano T, Yamada J
机构信息
Faculty of Fisheries, Hokkaido University, Japan.
出版信息
Gen Comp Endocrinol. 1992 Apr;86(1):90-5. doi: 10.1016/0016-6480(92)90129-8.
Effects of salmon and eel growth hormones (GHs) on bone metabolism in rainbow trout (Oncorhynchus mykiss) were studied using histomorphometry of their pharyngeal bones. When salmon GH (sGH) was injected intraperitoneally at a dose of 0.01 or 0.1 microgram/g/week for 10 times into fed trout, body growth in both length and weight was accelerated. Formation and resorption of bone were enhanced only by the higher dose of sGH. When a cholesterol pellet containing recombinant eel GH (reGH-pellet) was implanted subcutaneously into starved trout for 1 week (37 micrograms reGH/18 g fish), formation and resorption of bone increased, although activity of bone formation was low. The results indicate that the GHs increased both formation and resorption of bone, regardless of the nutritional status of the fish.
利用虹鳟（Oncorhynchus mykiss）咽骨的组织形态计量学方法，研究了鲑鱼生长激素（GHs）和鳗鱼生长激素对虹鳟骨代谢的影响。当以0.01或0.1微克/克/周的剂量腹腔注射鲑鱼生长激素（sGH），连续10次注射到喂食的虹鳟体内时，其体长和体重的生长均加速。仅较高剂量的sGH增强了骨的形成和吸收。当将含有重组鳗鱼生长激素的胆固醇丸剂（reGH-丸剂）皮下植入饥饿的虹鳟体内1周（37微克reGH/18克鱼）时，尽管骨形成活性较低，但骨的形成和吸收增加。结果表明，无论鱼的营养状况如何，生长激素均增加了骨的形成和吸收。
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