Yada T, Nagae M, Moriyama S, Azuma T
Nikko Branch, National Research Institute of Aquaculture, Nikko, Tochigi, 321-1661, Japan.
Gen Comp Endocrinol. 1999 Jul;115(1):46-52. doi: 10.1006/gcen.1999.7282.
Immunoglobulin M (IgM) is a major component of the humoral immune system of teleosts. This study examines the effects of hypophysectomy and subsequent replacement with prolactin (PRL) or growth hormone (GH) upon the plasma IgM levels of the rainbow trout (Oncorhynchus mykiss). Plasma IgM levels of the hypophysectomized fish were decreased to 30% of those in sham-operated fish 1 or 4 weeks after operation. Implantation of a cholesterol pellet containing salmon PRL or GH restored plasma IgM levels of the hypophysectomized fish, suggesting important roles for PRL and GH in the regulation of circulating IgM level in trout.
免疫球蛋白M（IgM）是硬骨鱼体液免疫系统的主要组成部分。本研究考察了垂体切除以及随后用催乳素（PRL）或生长激素（GH）替代对虹鳟（Oncorhynchus mykiss）血浆IgM水平的影响。垂体切除的鱼在手术后1周或4周时，其血浆IgM水平降至假手术鱼的30%。植入含鲑鱼PRL或GH的胆固醇丸粒可恢复垂体切除鱼的血浆IgM水平，这表明PRL和GH在调节鳟鱼循环IgM水平中起重要作用。
