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使用EXOMIO 3-D CT模拟进行肺癌连续颅外放射外科手术的方法学。

Methodology of continuous extracranial radiosurgery for lung cancer using EXOMIO 3-D CT simulation.

作者信息

Strassmann Gerd, Vacha Peter, Braun Isabell, Richter Detlev, Engenhart-Cabillic Rita

机构信息

Department of Radiooncology, University of Marburg, Germany.

出版信息

Strahlenther Onkol. 2004 Apr;180(4):241-4. doi: 10.1007/s00066-004-1169-6.

DOI:10.1007/s00066-004-1169-6
PMID:15057435
Abstract

BACKGROUND

It is well known that precision can be achieved using radiosurgery for brain tumors. This method can be extended to treat localized lung tumors and lung metastases.

MATERIAL AND METHODS

The conventional procedure of extracranial radiosurgery is contained in the following steps: adaptation of the vacuum mattress, planning CT, three-dimensional (3-D) treatment planning, CT repositioning, and irradiation. In the new procedure of continuous extracranial radiosurgery, a short treatment planning is often used for simple target shapes (spherical, rotation-symmetrical), and the irradiation follows directly after the planning procedure. During continuous extracranial radiosurgery, the patient has to lie still in the body frame from the planning CT to irradiation. Fast treatment planning is performed by using multileafs and EXOMIO (Medintec, Bochum, Germany), a software for CT simulation. The high quality of the digitally reconstructed radiographs (DRRs) of each field enables a high precision in dose application by the comparison with the verification radiograph and the DRR (Elekta iView, Hamburg, Germany).

RESULTS

In five lung cancer patients the average time for the complete procedure from planning CT to irradiation was 107 min (range: 91-124 min). The mean positioning accuracy of the patient in the vacuum bed (total shift) was 3.3 mm (range: 2.9-4.7 mm).

CONCLUSION

Continuous extracranial radiosurgery can be performed for small peripheral lung tumors or metastases and is optimizing the conventional procedure. It is of special interest to clinics with restricted CT capacity.

摘要

背景

众所周知,使用放射外科治疗脑肿瘤可实现精准治疗。该方法可扩展至治疗局限性肺肿瘤及肺转移瘤。

材料与方法

颅外放射外科的传统流程包含以下步骤:适配真空床垫、计划CT、三维(3-D)治疗计划、CT重新定位以及照射。在连续颅外放射外科的新流程中,对于简单的靶区形状(球形、旋转对称)常采用简短的治疗计划,且在计划流程后直接进行照射。在连续颅外放射外科过程中,患者必须从计划CT到照射期间一直静止地躺在体架中。通过使用多叶准直器和EXOMIO(德国波鸿的Medintec公司)这一用于CT模拟的软件来进行快速治疗计划。每个射野的数字重建X线片(DRR)质量很高,通过与验证X线片和DRR(德国汉堡的医科达iView)进行比较,能够在剂量应用方面实现高精度。

结果

在5例肺癌患者中,从计划CT到照射的整个流程平均时间为107分钟(范围:91 - 124分钟)。患者在真空床中的平均定位精度(总位移)为3.3毫米(范围:2.9 - 4.7毫米)。

结论

连续颅外放射外科可用于治疗小的周围型肺肿瘤或转移瘤,并且正在优化传统流程。对于CT能力有限的诊所而言,它具有特别的意义。

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