Feeny D, Blanchard C M, Mahon J L, Bourne R, Rorabeck C, Stitt L, Webster-Bogaert S
Institute of Health Economics, Edmonton, Alberta, Canada.
Qual Life Res. 2004 Feb;13(1):15-22. doi: 10.1023/B:QURE.0000015307.33811.2d.
Are utility scores for hypothetical health states stable over time even when the health of the patient changes dramatically? Can investigators who use scores for hypothetical states be confident about the stability of those scores? The first purpose is to assess the stability of standard gamble utility scores for three hypothetical health states describing mild, moderate, and severe osteoarthritis (OA) (test-retest reliability). How should investigators interpret utility scores? The second purpose is to provide evidence on the marker-state approach to assist in interpreting utility scores.
SG scores for three hypothetical marker states and the patient's current state were obtained at multiple times in a longitudinal study of elective total hip arthroplasty (THA). SG scores for current health increased from a mean of 0.59 pre-surgery to 0.76 post-surgery.
Test-retest reliability was assessed using the intra-class correlation coefficient (ICC). The effects of time on scores were analysed using an analysis of covariance.
At the group level the marker-state scores were stable. Mean scores for mild, moderate, and severe OA were 0.69, 0.61, and 0.41. With respect to test-retest reliability, ICCs varied from 0.49 to 0.62. In general, time did not affect the scores for the three marker states.
Group-level standard gamble scores are stable. At the individual level scores for hypothetical health states are somewhat stable over time. The marker states assist in interpretation indicating that, on average, THA converted moderate OA to better than mild.
即使患者的健康状况发生显著变化,假设健康状态的效用分数随时间推移是否稳定?使用假设状态分数的研究人员能否对这些分数的稳定性有信心?第一个目的是评估描述轻度、中度和重度骨关节炎(OA)的三种假设健康状态的标准博弈效用分数的稳定性(重测信度)。研究人员应如何解释效用分数?第二个目的是提供关于标记状态方法的证据,以协助解释效用分数。
在一项关于择期全髋关节置换术(THA)的纵向研究中,多次获得了三种假设标记状态以及患者当前状态的标准博弈分数。当前健康状态的标准博弈分数从术前的平均0.59增加到术后的0.76。
使用组内相关系数(ICC)评估重测信度。使用协方差分析来分析时间对分数的影响。
在组水平上,标记状态分数稳定。轻度、中度和重度OA的平均分数分别为0.69、0.61和0.41。关于重测信度,组内相关系数在0.49至0.62之间变化。总体而言,时间并未影响三种标记状态的分数。
组水平的标准博弈分数是稳定的。在个体水平上,假设健康状态的分数随时间略有稳定。标记状态有助于解释,表明平均而言,全髋关节置换术将中度OA转变为优于轻度的状态。