Colla Simona, Sammarelli Gabriella, Crugnola Monica, Ascani Stefano, Sabbatini Elena, Bonomini Sabrina, Hojden Magda, Craviotto Luisa, De Celis Isabel, Morandi Francesca, Caramatti Cecilia, Rizzoli Vittorio, Giuliani Nicola
Chair of Hematology and BMT Unit, University of Parma, Via Gramsci 14, 43100 Parma, Italy.
Eur J Haematol. 2004 May;72(5):361-5. doi: 10.1111/j.1600-0609.2004.00222.x.
In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.
在本研究中，我们描述了一例极为罕见的病例，即费城染色体阳性的慢性髓性白血病急性巨核细胞和B淋巴细胞混合母细胞危象与慢性淋巴细胞白血病并存。已进行了形态学、免疫表型和细胞遗传学研究以对该病例进行特征描述，并确定两种疾病的起源。在传统治疗失败后，该患者接受了伊马替尼治疗，获得了完全血液学和细胞遗传学缓解，骨髓纤维化明显减轻。
