Liu Zhao-sheng, Xie Li-xin, Shi Wei-yun, Li Shao-wei, Cai Qing, Bei Jian-zhong, Wang Shen-guo
Shandong Eye Institute & Hospital, Qingdao 266071, China.
Zhonghua Yan Ke Za Zhi. 2004 Feb;40(2):108-12.
To study the drug concentration in the aqueous humor and the biocompatibility of cyclosporine A drug delivery system (CsA DDS) implanting in the anterior chamber.
There were four different types of CsA DDS which had different biodegradable polymers as the vector or had different ratio between CsA and the vector. Thirty-six New Zealand rabbits were randomly divided into 4 groups to receive the 4 different types of CsA DDS. Three of nine New Zealand rabbits received CsA DDS in one eye and empty DDS in the contralateral eye. Three rabbits received empty DDS in one eye and keratotomy in the contralateral eye. Another three rabbits received CsA DDS in one eye and keratotomy in the contralateral eye. All DDS were implanted into the anterior chamber. The follow-up period was 12 weeks.
No significantly acute or chronic intraocular toxic effects were found in all groups. The CsA release rate was different in these 4 groups. In type A and B CsA DDS, the drug released fast and maintained for a short period; in type C and D, the drug released slowly and could be maintained for a long period.
CsA DDS implanted in the anterior chamber can be well tolerated in rabbit eyes. CsA DDS is a promising approach for the prevention (type C and D CsA DDS) and treatment (type A and B CsA DDS) of corneal graft rejection.
研究环孢素A给药系统（CsA DDS）植入前房后的房水药物浓度及生物相容性。
有四种不同类型的CsA DDS，其载体为不同的可生物降解聚合物，或CsA与载体的比例不同。36只新西兰兔随机分为4组，分别接受4种不同类型的CsA DDS。9只新西兰兔中，3只兔一只眼植入CsA DDS，对侧眼植入空白DDS。3只兔一只眼植入空白DDS，对侧眼角膜切开。另外3只兔一只眼植入CsA DDS，对侧眼角膜切开。所有DDS均植入前房。随访期为12周。
所有组均未发现明显的急性或慢性眼内毒性作用。这4组CsA的释放速率不同。A、B型CsA DDS药物释放快，但维持时间短；C、D型药物释放慢，可长期维持。
CsA DDS植入兔眼前房能被很好地耐受。CsA DDS是预防（C、D型CsA DDS）和治疗（A、B型CsA DDS）角膜移植排斥反应的一种有前景的方法。
