质粒分配与后分离杀伤系统之间的相互作用。
Interplay between plasmid partition and postsegregational killing systems.
作者信息
Brendler Therese, Reaves Lucretia, Austin Stuart
机构信息
Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702-1201, USA.
出版信息
J Bacteriol. 2004 Apr;186(8):2504-7. doi: 10.1128/JB.186.8.2504-2507.2004.
Abstract
Active partition systems and postsegregational killing (PSK) systems are present together in naturally occurring low-copy-number plasmids. Theory suggests that PSK may act as the ultimate determinant of plasmid retention, whereas the partition system may minimize the growth penalty to the host, resulting in a near-ideal symbiosis when the systems combine. Here, we prove the validity of this principle for a specific case involving the P1par system and the mvp PSK system.
摘要
活性分配系统和后分离杀伤（PSK）系统共同存在于天然存在的低拷贝数质粒中。理论表明，PSK可能是质粒保留的最终决定因素，而分配系统可能会使对宿主的生长代价最小化，当这两个系统结合时会形成近乎理想的共生关系。在这里，我们证明了这一原理在涉及P1par系统和mvp PSK系统的特定情况下的有效性。
相似文献
1
Interplay between plasmid partition and postsegregational killing systems.质粒分配与后分离杀伤系统之间的相互作用。
J Bacteriol. 2004 Apr;186(8):2504-7. doi: 10.1128/JB.186.8.2504-2507.2004.
2
Surprising dependence on postsegregational killing of host cells for maintenance of the large virulence plasmid of Shigella flexneri.福氏志贺氏菌大毒力质粒的维持对宿主细胞的分离后杀伤存在惊人的依赖性。
J Bacteriol. 2005 Apr;187(8):2768-73. doi: 10.1128/JB.187.8.2768-2773.2005.
3
Postsegregational killing does not increase plasmid stability but acts to mediate the exclusion of competing plasmids.后分离杀伤作用不会提高质粒稳定性，而是起到介导排除竞争性质粒的作用。
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12643-8. doi: 10.1073/pnas.220077897.
4
Contribution of different segments of the par region to stable maintenance of the broad-host-range plasmid RK2.par区域不同片段对广宿主范围质粒RK2稳定维持的贡献。
J Bacteriol. 1997 Oct;179(20):6472-9. doi: 10.1128/jb.179.20.6472-6479.1997.
5
Toxin Kid uncouples DNA replication and cell division to enforce retention of plasmid R1 in Escherichia coli cells.毒素小子将 DNA 复制和细胞分裂解偶联，以强制保留大肠杆菌细胞中的质粒 R1。
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2734-9. doi: 10.1073/pnas.1308241111. Epub 2014 Jan 21.
6
The stability region of the large virulence plasmid of Shigella flexneri encodes an efficient postsegregational killing system.福氏志贺氏菌大毒力质粒的稳定区编码一种高效的后分离杀伤系统。
J Bacteriol. 2000 May;182(9):2416-21. doi: 10.1128/JB.182.9.2416-2421.2000.
7
Stability of EcoRI restriction-modification enzymes in vivo differentiates the EcoRI restriction-modification system from other postsegregational cell killing systems.EcoRI限制修饰酶在体内的稳定性使EcoRI限制修饰系统有别于其他的分离后细胞杀伤系统。
J Bacteriol. 2005 Oct;187(19):6612-21. doi: 10.1128/JB.187.19.6612-6621.2005.
8
Characterization of the stable maintenance properties of the par region of broad-host-range plasmid RK2.广宿主范围质粒RK2的par区域稳定维持特性的表征
J Bacteriol. 1996 Apr;178(7):2086-93. doi: 10.1128/jb.178.7.2086-2093.1996.
9
Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells.独特的质粒维持功能类型：无质粒细胞的后分离杀伤作用。
Proc Natl Acad Sci U S A. 1986 May;83(10):3116-20. doi: 10.1073/pnas.83.10.3116.
10
Partition of P1 plasmids in Escherichia coli mukB chromosomal partition mutants.P1质粒在大肠杆菌mukB染色体分配突变体中的分配
J Bacteriol. 1995 May;177(9):2381-6. doi: 10.1128/jb.177.9.2381-2386.1995.
引用本文的文献
1
The combination of active partitioning and toxin-antitoxin systems is most advantageous for low-copy plasmid fitness.主动分区与毒素-抗毒素系统的结合对低拷贝质粒的适应性最为有利。
Nat Commun. 2025 Aug 1;16(1):7078. doi: 10.1038/s41467-025-62473-8.
2
Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative O104:H4 outbreak strain.非志贺毒素产生性肠聚集性O104:H4暴发菌株毒力质粒的遗传与表型分析
Microbiology (Reading). 2025 Mar;171(3). doi: 10.1099/mic.0.001550.
3
RNA Regulated Toxin-Antitoxin Systems in Pathogenic Bacteria.致病细菌中的RNA调控毒素-抗毒素系统
Front Cell Infect Microbiol. 2021 May 18;11:661026. doi: 10.3389/fcimb.2021.661026. eCollection 2021.
4
Combinatorial strategy towards the efficient expression of lipoxygenase in Escherichia coli at elevated temperatures.组合策略可实现脂氧合酶在大肠杆菌中于高温下的高效表达。
Appl Microbiol Biotechnol. 2020 Dec;104(23):10047-10057. doi: 10.1007/s00253-020-10941-0. Epub 2020 Oct 10.
5
Maintenance of the virulence plasmid in Shigella flexneri is influenced by Lon and two functional partitioning systems.福氏志贺菌毒力质粒的维持受 Lon 和两个功能分区系统的影响。
Mol Microbiol. 2019 May;111(5):1355-1366. doi: 10.1111/mmi.14225. Epub 2019 Mar 22.
6
Within-host competition selects for plasmid-encoded toxin-antitoxin systems.宿主内竞争选择了质粒编码的毒素-抗毒素系统。
Proc Biol Sci. 2010 Oct 22;277(1697):3149-55. doi: 10.1098/rspb.2010.0831. Epub 2010 May 26.
7
Characterization of a novel partition system encoded by the delta and omega genes from the streptococcal plasmid pSM19035.对来自链球菌质粒pSM19035的δ和ω基因编码的新型分配系统的表征
J Bacteriol. 2006 Jun;188(12):4362-72. doi: 10.1128/JB.01922-05.
8
The pCoo plasmid of enterotoxigenic Escherichia coli is a mosaic cointegrate.产肠毒素大肠杆菌的pCoo质粒是一种嵌合共整合体。
J Bacteriol. 2005 Sep;187(18):6509-16. doi: 10.1128/JB.187.18.6509-6516.2005.
9
Surprising dependence on postsegregational killing of host cells for maintenance of the large virulence plasmid of Shigella flexneri.福氏志贺氏菌大毒力质粒的维持对宿主细胞的分离后杀伤存在惊人的依赖性。
J Bacteriol. 2005 Apr;187(8):2768-73. doi: 10.1128/JB.187.8.2768-2773.2005.
本文引用的文献
1
Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest.毒素-抗毒素系统：质粒维持、程序性细胞死亡及细胞周期阻滞
Science. 2003 Sep 12;301(5639):1496-9. doi: 10.1126/science.1088157.
2
Dynamic cellular location of bacterial plasmids.细菌质粒的动态细胞定位
Curr Opin Microbiol. 2002 Dec;5(6):586-90. doi: 10.1016/s1369-5274(02)00370-3.
3
An efficient recombination system for chromosome engineering in Escherichia coli.一种用于大肠杆菌染色体工程的高效重组系统。
Proc Natl Acad Sci U S A. 2000 May 23;97(11):5978-83. doi: 10.1073/pnas.100127597.
4
The stability region of the large virulence plasmid of Shigella flexneri encodes an efficient postsegregational killing system.福氏志贺氏菌大毒力质粒的稳定区编码一种高效的后分离杀伤系统。
J Bacteriol. 2000 May;182(9):2416-21. doi: 10.1128/JB.182.9.2416-2421.2000.
5
Plasmid maintenance functions of the large virulence plasmid of Shigella flexneri.福氏志贺氏菌大毒力质粒的质粒维持功能
J Bacteriol. 1997 Jun;179(11):3670-5. doi: 10.1128/jb.179.11.3670-3675.1997.
6
7
Programmed cell death in bacterial populations.细菌群体中的程序性细胞死亡。
Science. 1995 Feb 10;267(5199):836-7. doi: 10.1126/science.7846528.
8
Programmed cell death in bacteria: proteic plasmid stabilization systems.细菌中的程序性细胞死亡：蛋白质质粒稳定系统。
Mol Microbiol. 1995 Jul;17(2):205-10. doi: 10.1111/j.1365-2958.1995.mmi_17020205.x.
9
A pSC101-derived plasmid which shows no sequence homology to other commonly used cloning vectors.一种源自pSC101的质粒，与其他常用克隆载体无序列同源性。
Gene. 1984 Nov;31(1-3):165-71. doi: 10.1016/0378-1119(84)90207-5.
10
Partition of unit-copy miniplasmids to daughter cells. III. The DNA sequence and functional organization of the P1 partition region.单位拷贝型小质粒向子细胞的分配。III. P1分配区域的DNA序列及功能组织
J Mol Biol. 1985 Sep 20;185(2):261-72. doi: 10.1016/0022-2836(85)90402-4.
Zotero 插件