Hoffmann Martha, Chott Andreas, Püspök Andreas, Jäger Ulrich, Kletter Kurt, Raderer Markus
Department of Nuclear Medicine, University of Vienna, Vienna, Austria.
Ann Hematol. 2004 May;83(5):276-8. doi: 10.1007/s00277-003-0827-6. Epub 2003 Dec 12.
18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) has been used as a potential tool for imaging nodal follicular lymphoma (FL) and extranodal spread. As primary intestinal FL is increasingly being recognized, we have performed a study to investigate the usefulness of 18F-FDG-PET for staging of extranodal FL within the gastrointestinal tract. In eight patients with a diagnosis of FL localized in the duodenum (six cases in stage I and one each in stages II and IV, respectively) whole body 18F-FDG-PET scans were performed. Seven patients with duodenal FL were rated WHO grade 1 and one had FL grade 3, while both patients with secondary spread had FL WHO grade 1. All patients were imaged before initiation of therapy. None of the patients with primary duodenal FL showed pathologically elevated 18F-FDG uptake. 18F-FDG-PET findings were not influenced by histological grade or proliferative activity of FL. These findings suggest that 18F-FDG-PET is not useful for clinical assessment of primary duodenal FL.
18F-氟脱氧葡萄糖正电子发射断层扫描（18F-FDG-PET）已被用作成像淋巴结滤泡性淋巴瘤（FL）和结外扩散的一种潜在工具。随着原发性肠道FL越来越受到认可，我们开展了一项研究，以调查18F-FDG-PET在胃肠道结外FL分期中的作用。对8例诊断为局限于十二指肠的FL患者（6例为I期，分别有1例为II期和IV期）进行了全身18F-FDG-PET扫描。7例十二指肠FL患者WHO分级为1级，1例为3级，而2例有继发性扩散的患者均为WHO 1级FL。所有患者在开始治疗前均进行了成像。原发性十二指肠FL患者均未显示病理上18F-FDG摄取升高。18F-FDG-PET检查结果不受FL组织学分级或增殖活性的影响。这些结果表明，18F-FDG-PET对原发性十二指肠FL的临床评估无用。
