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[在修复缺陷型雌性果蝇mei-41 [D5]和mus209 [B1]与受辐照雄性果蝇M5的杂交后代中,未受辐照的X染色体上诱导突变]

[Induction of mutations in unirradiated X-chromosome of Drosophila melanogaster hybrids of repair deficient females mei-41 [D5] and mus209 [B1] and irradiated males M5].

作者信息

Shaposhnikov M V, Zaĭnullin V G, Belogolov I N

机构信息

Institute of Biology Ural Division, Russian Academy of Sciences, Syktyvkar, 167982 Russia.

出版信息

Radiats Biol Radioecol. 2004 Jan-Feb;44(1):15-7.

Abstract

It has been analyzed the frequency of the recessive lethal mutations in the unirradiated X-chromosome of Drosophila. Females of wild type (CS) as well as of error-prone (mei-41) and error-free (mus209) mutant strains were used. In CS hybrids the increasing of the mutation rate (p < 0.05) was found. In muc209 hybrids the mutation rate was not affected. In mei-41 hybrids the tendency to decreasing of the mutation rate was found. The obtained results demonstrate the possible role of error-prone repair in the inducing of mutations in the unirradiated X-chromosome in the presence of irradiated homologue.

摘要

已经分析了果蝇未受辐射的X染色体中隐性致死突变的频率。使用了野生型(CS)以及易出错(mei-41)和无差错(mus209)突变株的雌性果蝇。在CS杂种中发现突变率增加(p < 0.05)。在muc209杂种中,突变率未受影响。在mei-41杂种中发现了突变率下降的趋势。所得结果表明,在存在受辐射同源物的情况下,易出错修复可能在未受辐射的X染色体中诱导突变中发挥作用。

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