Mishra S, Patwari A K, Anand V K, Pillai P K, Aneja S, Chandra J, Sharma D
Department of Pediatrics, Lady Hardinge Medical College, New Delhi.
Indian Pediatr. 1992 Apr;29(4):443-8.
Forty six blood culture positive cases were studied during the current outbreak of multidrug resistant typhoid fever (MRTF). The present outbreak was caused by E1 phage type and organisms were resistant to all commonly used drugs for the treatment of typhoid fever, viz., chloramphenicol (78%), co-trimoxazole (76%) and ampicillin (68%). Treatment failures with chloramphenicol (45.5%) corroborated well with in vitro resistance. No treatment failure was seen with chloramphenicol and ceftriaxone, when these drugs were used in cases infected with sensitive strains. Among the alternative drugs used in cases with in vitro sensitivity, successful clinical response was seen with ceftriaxone (4/4) and cefotaxime (8/9) as compared to cephalexin (3/5) or a combination of cephalexin and furazolidone (9/12).
在当前耐多药伤寒热（MRTF）疫情期间，对46例血培养阳性病例进行了研究。本次疫情由E1噬菌体类型引起，病原体对所有常用的伤寒热治疗药物均耐药，即氯霉素（78%）、复方新诺明（76%）和氨苄西林（68%）。氯霉素治疗失败率（45.5%）与体外耐药情况相符。当氯霉素和头孢曲松用于感染敏感菌株的病例时，未见治疗失败。在体外敏感的病例中使用的替代药物中，与头孢氨苄（3/5）或头孢氨苄与呋喃唑酮联合使用（9/12）相比，头孢曲松（4/4）和头孢噻肟（8/9）观察到了成功的临床反应。
