Mayer Ljiljana, Romić Zeljko, Skreb Franjo, Bacić-Vrca Vesna, Cepelak Ivana, Zanić-Grubisić Tihana, Kirin Marijan
Department of Laboratory Medicine, Dubrava University Hospital, Zagreb, Croatia.
Clin Chem Lab Med. 2004 Feb;42(2):154-8. doi: 10.1515/CCLM.2004.028.
Hyperthyroidism is a hypermetabolic state accompanied by increased oxygen utilization, increased production of reactive oxygen species and consequentially measurable changes in antioxidative factors. Therefore, the activities of whole blood glutathione peroxidase (GPx) and erythrocyte superoxide dismutase (SOD), total antioxidant status (TAS) in serum and erythrocytes, and serum urate and transferrrin concentrations were determined in 70 women: 14 with newly diagnosed Graves' disease (group A); 28 with hyperthyroidism on therapy with methimazole (group B, divided into two subgroups, B1 and B2) and 28 healthy women (group C). In comparison with control group C, GPx activity was significantly decreased in all patient groups (p < 0.05), whereas SOD activity was significantly decreased in group A (p < 0.01) and significantly increased in group B (p < 0.01). In comparison with the control group, serum TAS activity was significantly decreased in group A, and erythrocyte TAS activity in all patient groups. Study results suggest that the impaired antioxidative factor balance leads to the development and presence of oxidative stress in women with hyperthyroidism. The severity of these alterations, considered contradictory by some authors, appears to depend on the use of therapy.
甲状腺功能亢进是一种高代谢状态，伴有氧利用增加、活性氧生成增加以及抗氧化因子的相应可测量变化。因此，我们测定了70名女性的全血谷胱甘肽过氧化物酶（GPx）和红细胞超氧化物歧化酶（SOD）活性、血清和红细胞中的总抗氧化状态（TAS）以及血清尿酸盐和转铁蛋白浓度，其中14名是新诊断的格雷夫斯病患者（A组）；28名接受甲巯咪唑治疗的甲状腺功能亢进患者（B组，分为两个亚组B1和B2）以及28名健康女性（C组）。与对照组C相比，所有患者组的GPx活性均显著降低（p < 0.05），而A组的SOD活性显著降低（p < 0.01），B组的SOD活性显著升高（p < 0.01）。与对照组相比，A组的血清TAS活性显著降低，所有患者组的红细胞TAS活性均降低。研究结果表明，抗氧化因子平衡受损导致甲状腺功能亢进女性出现氧化应激并持续存在。这些变化的严重程度，一些作者认为相互矛盾，似乎取决于治疗的使用情况。
