Frey Jacques
University of Saint-Etienne, Saint-Etienne, France.
Clin Chem Lab Med. 2004 Jan;42(1):9-12. doi: 10.1515/CCLM.2004.003.
The relationship between ageing and nutrition is considered with collagen as the intermediate target. Some data showed that diet restriction resulted in decreased collagen accumulation and collagen ageing. Conversely, being overweight reduced the lifespan and increased collagen ageing. Collagen ageing, which includes low turnover and glycoxidation, involves an increase in both stiffness and weakness. Their consequences concern all tissues including those with vital importance such as cartilage, heart ventricle or arterial wall.
以胶原蛋白作为中间靶点来考量衰老与营养之间的关系。一些数据表明，饮食限制会导致胶原蛋白积累减少和胶原蛋白老化减缓。相反，超重会缩短寿命并加速胶原蛋白老化。胶原蛋白老化包括低周转率和糖氧化，会导致硬度增加和韧性降低。其后果涉及所有组织，包括软骨、心室或动脉壁等至关重要的组织。
