Tortu Stephanie, McMahon James M, Pouget Enrique R, Hamid Rahul
Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Subst Use Misuse. 2004 Jan;39(2):211-24. doi: 10.1081/ja-120028488.
This study examined sharing noninjection drug implements as a risk factor for hepatitis C (HCV) infection among women drug users (n = 123) with no history of drug injection. Participants were street-recruited from East Harlem, New York City, between October 1997 and June 1999. Participants were administered a survey measuring risk factors for HCV. Prevalence of HCV and HIV infections was 19.5% and 14.6%, respectively. Multiple logistic regression determined significant associations between sharing noninjection drug-use implements and HCV infection. "Ever shared both oral and intranasal noninjection drug implements" was independently associated with HCV infection [Odds ratio (OR) 2.83; Confidence interval (CI) 1.04, 7.72; p = 0.04]; "ever shared noninjected heroin implements with an injector" was a trend (OR 3.06; CI .85, 10.79; p = 0.08). The strongest association between sharing noninjection drug-use implements and HCV infection was found among HIV positive individuals (chi2 = 8.8, 1 d.f., p < 0.01). These findings, if supported by future research, indicate a need to reassess policies regarding HCV infection.
本研究调查了共用非注射吸毒器具作为无注射吸毒史的女性吸毒者（n = 123）丙型肝炎（HCV）感染风险因素的情况。1997年10月至1999年6月期间，从纽约市东哈莱姆区街头招募了参与者。对参与者进行了一项测量HCV风险因素的调查。HCV和HIV感染率分别为19.5%和14.6%。多因素logistic回归分析确定了共用非注射吸毒器具与HCV感染之间的显著关联。“曾共用口服和鼻用非注射吸毒器具”与HCV感染独立相关[比值比（OR）2.83；置信区间（CI）1.04，7.72；p = 0.04]；“曾与注射吸毒者共用非注射海洛因器具”有一定趋势（OR 3.06；CI 0.85，10.79；p = 0.08）。在HIV阳性个体中发现共用非注射吸毒器具与HCV感染之间的关联最强（卡方= 8.8，自由度= 1，p < 0.01）。如果未来研究支持这些发现，则表明需要重新评估有关HCV感染的政策。
