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共用非注射吸毒器具作为丙型肝炎的一个风险因素。

Sharing of noninjection drug-use implements as a risk factor for hepatitis C.

作者信息

Tortu Stephanie, McMahon James M, Pouget Enrique R, Hamid Rahul

机构信息

Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.

出版信息

Subst Use Misuse. 2004 Jan;39(2):211-24. doi: 10.1081/ja-120028488.

Abstract

This study examined sharing noninjection drug implements as a risk factor for hepatitis C (HCV) infection among women drug users (n = 123) with no history of drug injection. Participants were street-recruited from East Harlem, New York City, between October 1997 and June 1999. Participants were administered a survey measuring risk factors for HCV. Prevalence of HCV and HIV infections was 19.5% and 14.6%, respectively. Multiple logistic regression determined significant associations between sharing noninjection drug-use implements and HCV infection. "Ever shared both oral and intranasal noninjection drug implements" was independently associated with HCV infection [Odds ratio (OR) 2.83; Confidence interval (CI) 1.04, 7.72; p = 0.04]; "ever shared noninjected heroin implements with an injector" was a trend (OR 3.06; CI .85, 10.79; p = 0.08). The strongest association between sharing noninjection drug-use implements and HCV infection was found among HIV positive individuals (chi2 = 8.8, 1 d.f., p < 0.01). These findings, if supported by future research, indicate a need to reassess policies regarding HCV infection.

摘要

本研究调查了共用非注射吸毒器具作为无注射吸毒史的女性吸毒者(n = 123)丙型肝炎(HCV)感染风险因素的情况。1997年10月至1999年6月期间,从纽约市东哈莱姆区街头招募了参与者。对参与者进行了一项测量HCV风险因素的调查。HCV和HIV感染率分别为19.5%和14.6%。多因素logistic回归分析确定了共用非注射吸毒器具与HCV感染之间的显著关联。“曾共用口服和鼻用非注射吸毒器具”与HCV感染独立相关[比值比(OR)2.83;置信区间(CI)1.04,7.72;p = 0.04];“曾与注射吸毒者共用非注射海洛因器具”有一定趋势(OR 3.06;CI 0.85,10.79;p = 0.08)。在HIV阳性个体中发现共用非注射吸毒器具与HCV感染之间的关联最强(卡方= 8.8,自由度= 1,p < 0.01)。如果未来研究支持这些发现,则表明需要重新评估有关HCV感染的政策。

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