Wainberg Mark A
McGill University AIDS Centre, Lady Davis Institute, Sir Mortimer B. Davis-Jewish General Hospital, Montréal, Que.
Clin Invest Med. 2004 Feb;27(1):51-8.
Infection by HIV-1 is characterized by genetic diversity wherein distinct viral subtypes (clades A, B, C, D, E, F, G, K and O) are expanding in different geographic regions. With respect to HIV-1 sensitivity to antiretroviral drugs and drug resistance, increasing evidence suggests that all clades probably display similar sensitivity to antiviral drugs, but viruses from some subtypes and geographic regions have a greater propensity than other viral variants to develop resistance to certain drugs. There is an urgency to make anti-HIV drugs available to all who are in need, regardless of ability to pay.
HIV-1感染的特点是基因多样性,不同的病毒亚型(A、B、C、D、E、F、G、K和O组)在不同地理区域不断扩散。关于HIV-1对抗逆转录病毒药物的敏感性和耐药性,越来越多的证据表明,所有组的病毒对抗病毒药物可能表现出相似的敏感性,但某些亚型和地理区域的病毒比其他病毒变体更易对某些药物产生耐药性。迫切需要让所有有需要的人都能获得抗HIV药物,无论其支付能力如何。