Desai Mayura M, Pal Ramprasad B, Banker Dushyant D
Department of Microbiology, Sir Hurkisondas Nurrotumdas Medical Research Society, Sir Hurkisondas Nurrotumdas Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai 400004, India.
Transfus Apher Sci. 2004 Apr;30(2):111-7. doi: 10.1016/j.transci.2003.10.006.
The hepatitis G virus (HGV) or GB virus C (GBV-C) was discovered in 1995 as a putative agent of post-transfusion, non-A-E hepatitis. The present study was carried out with the aim to find the prevalence of this virus among various subject groups at risk for parenteral transmission as well as in healthy control subjects both individually and along with other parenterally transmitted hepatitis viruses. Of the 402 subjects tested, 6.22% were positive for the HBsAg surface antigen, 7.21% were positive for HCV RNA while only 2.24% were seen to be carriers of the HGV/GBV-C RNA. All the HGV/GBV-C positive cases were either multi-transfused thalassaemic subjects or hemodialysis patients. None of the healthy control subjects showed presence of the virus. Seven of the HGV/GBV-C positive subjects showed co-infection with one or more additional virological markers. Also, of the 9 HGV/GBV-C positive subjects, 5 showed elevated ALT levels while 4 showed elevated alkaline phosphatase levels. Overall our findings seem to indicate that HGV infections generally are asymptomatic, transient and self-limiting and the virus does not seem to show a very high prevalence among the Indian population.
庚型肝炎病毒（HGV）或GB病毒C（GBV-C）于1995年被发现，被认为是输血后非甲-戊型肝炎的病原体。本研究旨在查明该病毒在各种有经肠外传播风险的受试者群体以及健康对照受试者个体中的流行情况，同时也研究其与其他经肠外传播的肝炎病毒的关系。在接受检测的402名受试者中，6.22%的人乙肝表面抗原（HBsAg）呈阳性，7.21%的人丙肝病毒核糖核酸（HCV RNA）呈阳性，而只有2.24%的人被发现是庚型肝炎病毒/GB病毒C核糖核酸（HGV/GBV-C RNA）携带者。所有HGV/GBV-C阳性病例均为多次输血的地中海贫血患者或血液透析患者。健康对照受试者中无一例显示存在该病毒。7名HGV/GBV-C阳性受试者显示与一种或多种其他病毒学标志物合并感染。此外，在9名HGV/GBV-C阳性受试者中，5人的谷丙转氨酶（ALT）水平升高，4人的碱性磷酸酶水平升高。总体而言，我们的研究结果似乎表明，庚型肝炎病毒感染通常无症状、短暂且具有自限性，并且该病毒在印度人群中的流行率似乎不高。
