肿瘤性厌食：对室旁核中神经肽Y和单胺类物质的影响
Tumor anorexia: effects on neuropeptide Y and monoamines in paraventricular nucleus.
作者信息
Meguid Michael M, Ramos Eduardo J B, Laviano Alessandro, Varma Madhu, Sato Tomoi, Chen Chung, Qi Yong, Das Undurti N
机构信息
Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
出版信息
Peptides. 2004 Feb;25(2):261-6. doi: 10.1016/j.peptides.2004.01.012.
Paraventricular (PVN) concentrations of neuropeptide Y (NPY), serotonin (5-HT) and dopamine (DA) in anorectic tumor-bearing (TB) rats were measured before and after tumor resection. At onset of anorexia in TB versus non-tumor bearing (NTB) Controls 5-HT increased from 12.19+/-0.49 pg/microg to 14.89+/-0.81 pg/microg ( P<0.05 ) while DA and NPY decreased from 7.34+/-0.42 pg/microg to 4.97+/-0.56 pg/microg and 23.47+/-4.27 pg/microg to 13.64+/-1.44 pg/microg, respectively ( P<0.05 ). After tumor resection, these neuromediators normalized when compared to sham-operated NTB rats. NTB pair-fed Controls were also studied. We conclude that the increased 5-HT and the decreased DA and NPY concentrations in PVN are associated with cancer anorexia and that the NPY food stimulatory effect is linked to serotoninergic and dopaminergic systems in hypothalamus.
在肿瘤切除前后，对患有厌食症的荷瘤（TB）大鼠室旁核（PVN）中的神经肽Y（NPY）、5-羟色胺（5-HT）和多巴胺（DA）浓度进行了测量。在TB大鼠出现厌食症时，与无瘤（NTB）对照相比，5-HT从12.19±0.49 pg/μg增加到14.89±0.81 pg/μg（P<0.05），而DA和NPY分别从7.34±0.42 pg/μg降至4.97±0.56 pg/μg，以及从23.47±4.27 pg/μg降至13.64±1.44 pg/μg（P<0.05）。肿瘤切除后，与假手术的NTB大鼠相比，这些神经介质恢复正常。还对NTB配对喂养对照进行了研究。我们得出结论，PVN中5-HT升高以及DA和NPY浓度降低与癌症厌食症相关，并且NPY的食物刺激作用与下丘脑的5-羟色胺能和多巴胺能系统有关。
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