Asaumi Jun-Ichi, Yanagi Yoshinobu, Konouchi Hironobu, Hisatomi Miki, Matsuzaki Hidenobu, Kishi Kanji
Department of Oral and Maxillofacial Radiology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.
Oral Oncol. 2004 Jul;40(6):579-84. doi: 10.1016/j.oraloncology.2003.12.002.
Because malignant lymphoma, the second most common malignant tumor of the head and neck, and squamous cell carcinoma (SCC), the most common malignant tumor of the head and neck, require different treatments, it is important to be able to differentiate them. In the present study, we attempted to differentiate malignant lymphomas from SCCs using dynamic contrast-enhanced MRI (DCE-MRI). Seventeen lesions (in 8 cases) of malignant lymphoma and 30 cases of SCC were compared by DCE-MRI. Thirteen of 17 malignant lymphomas (76.5%) showed the maximum contrast index (CI) at 90-180 s, while 26 of 30 SCCs (86.7%) showed the maximum CI at a much faster 60-105 s. There was a statistically significant difference between SCC and malignant lymphoma in the time needed reach the maximum CI (p = 0.0177). There was also significant difference between SCC and malignant lymphoma in their maximum CIs (p < 0.001), with the maximum CIs of 29/30 SCCs (96.7%) above 2.0, while 12/17 malignant lymphomas (70.6%) showed CIs of less than 2.0. We consider these findings to be useful for distinguishing lymphomas from SCCs.
由于恶性淋巴瘤是头颈部第二常见的恶性肿瘤，而鳞状细胞癌（SCC）是头颈部最常见的恶性肿瘤，且二者需要不同的治疗方法，因此能够区分它们很重要。在本研究中，我们尝试使用动态对比增强磁共振成像（DCE-MRI）来区分恶性淋巴瘤和SCC。通过DCE-MRI对17个（8例）恶性淋巴瘤病变和30例SCC进行了比较。17个恶性淋巴瘤中有13个（76.5%）在90-180秒时显示出最大对比指数（CI），而30个SCC中有26个（86.7%）在快得多的60-105秒时显示出最大CI。SCC和恶性淋巴瘤在达到最大CI所需时间上存在统计学显著差异（p = 0.0177）。SCC和恶性淋巴瘤在最大CI方面也存在显著差异（p < 0.001），30个SCC中有29个（96.7%）的最大CI高于2.0，而17个恶性淋巴瘤中有12个（70.6%）的CI小于2.0。我们认为这些发现有助于区分淋巴瘤和SCC。
