de Jong Pim A, Ottink Mark D, Robben Simon G F, Lequin Maarten H, Hop Wim C J, Hendriks Johan J E, Paré Peter D, Tiddens Harm A W M
Department of Paediatric Pulmonology, Erasmus Medical Center Rotterdam, The Netherlands.
Radiology. 2004 May;231(2):434-9. doi: 10.1148/radiol.2312021393. Epub 2004 Apr 2.
To retrospectively compare thin-section computed tomographic (CT) scores obtained with five scoring systems for assessment of pulmonary disease in children with cystic fibrosis and to determine additional value of bronchial and arterial dimension measurements.
Scores obtained with five thin-section CT scoring systems were compared. A score of 0 indicated the absence of abnormalities; a higher score meant that more structural abnormalities were seen. Three observers assigned scores and then reassigned scores after intervals varying from 1-2 weeks to 1-2 months at review of thin-section CT scans obtained in 25 children with cystic fibrosis. Interobserver and intraobserver reliability was calculated with intraclass correlation coefficients. Quantitative measurements of bronchial and arterial dimensions were obtained. Thin-section CT scores were correlated (Spearman correlation) with bronchial and arterial dimensions and with results of pulmonary function tests (PFTs), such as forced expiratory volume in 1 second (FEV(1)).
Scores with all five scoring systems were reproducible, with intraclass correlation coefficients of 0.74 and higher (P <.05), and showed significant correlations with FEV(1) (R = -0.73 to -0.69, P <.01). Ratio of bronchial diameter to accompanying pulmonary arterial diameter was correlated with thin-section CT scores but not with FEV(1). Ratio of bronchial wall thickness to accompanying pulmonary arterial diameter was not correlated with thin-section CT scores or PFT results.
Thin-section CT scores were reproducible and were correlated with PFT results. Measurements of bronchial dimensions were not significantly related to scores or PFT results.
回顾性比较用于评估囊性纤维化患儿肺部疾病的五种评分系统所获得的薄层计算机断层扫描（CT）评分，并确定支气管和动脉尺寸测量的附加价值。
比较了五种薄层CT评分系统所获得的评分。0分表示无异常；分数越高意味着可见的结构异常越多。三名观察者对25例囊性纤维化患儿的薄层CT扫描结果进行评分，然后在1至2周或1至2个月的不同间隔后重新评分。通过组内相关系数计算观察者间和观察者内的可靠性。获得支气管和动脉尺寸的定量测量值。薄层CT评分与支气管和动脉尺寸以及肺功能测试（PFT）结果（如1秒用力呼气量（FEV₁））进行相关性分析（Spearman相关性）。
所有五种评分系统的评分均可重复，组内相关系数为0.74及更高（P <.05），并且与FEV₁显示出显著相关性（R = -0.73至-0.69，P <.01）。支气管直径与伴行肺动脉直径的比值与薄层CT评分相关，但与FEV₁无关。支气管壁厚度与伴行肺动脉直径的比值与薄层CT评分或PFT结果无关。
薄层CT评分具有可重复性，并且与PFT结果相关。支气管尺寸测量与评分或PFT结果无显著相关性。
