Rehwald Wolfgang G, Chen Enn-Ling, Kim Raymond J, Judd Robert M
Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, PO Box 3934, Durham, North Carolina 27710, USA.
Nat Med. 2004 May;10(5):545-9. doi: 10.1038/nm1027. Epub 2004 Apr 4.
Cardiovascular disease is primarily diagnosed using invasive X-ray cineangiography. Here we introduce a new concept in magnetic resonance imaging (MRI) that, for the first time, produces similar images noninvasively and without a contrast agent. Protons in moving blood are 'tagged' every few milliseconds as they travel through an arbitrary region in space. Simultaneous with ongoing tagging of new blood, previously tagged blood is maintained in a state of global coherent free precession (GCFP), which allows acquisition of consecutive movie frames as the heart pushes blood through the vascular bed. Body tissue surrounding the moving blood is never excited and therefore remains invisible. In 18 subjects, pulsating blood could be seen flowing through three-dimensional (3D) space for distances of up to 16 cm outside the stationary excitation region. These data underscore that our approach noninvasively characterizes both anatomy and blood flow in a manner directly analogous to invasive procedures.
心血管疾病主要通过侵入性X射线血管造影术进行诊断。在此，我们介绍磁共振成像（MRI）中的一个新概念，该概念首次能够在不使用造影剂的情况下非侵入性地生成类似图像。流动血液中的质子在穿过空间中的任意区域时，每隔几毫秒就会被“标记”一次。在持续标记新血液的同时，先前标记的血液保持在全局相干自由进动（GCFP）状态，这使得在心脏将血液推过血管床时能够获取连续的电影帧。流动血液周围的身体组织从未被激发，因此保持不可见。在18名受试者中，可以看到搏动的血液在静止激发区域外的三维（3D）空间中流动长达16厘米的距离。这些数据强调，我们的方法以一种与侵入性程序直接类似的方式非侵入性地表征了解剖结构和血流情况。
