Tanvetyanon T, Nand S
Cardinal Bernardin Cancer Center, 2160 S First Avenue, Maywood, IL 60153-3304, USA.
Ann Hematol. 2004 Mar;83(3):198-200. doi: 10.1007/s00277-003-0749-3. Epub 2003 Oct 8.
In vitro data suggest that arsenic compounds can suppress cell-mediated immunity by inducing apoptosis of T helper lymphocytes. We describe an occurrence of herpes zoster during treatment with arsenic trioxide (ATO) in two patients who were already in remission from acute promyelocytic leukemia and received ATO as consolidation treatment. During this complication, their leukocyte counts and differentials were within normal limits. Our report suggested the immunosuppressive effect of ATO in vivo. Both patients responded well to an oral antiviral. Clinicians should be aware of this complication during treatment with ATO since early antiviral treatment may help avoid complications including post-herpetic neuralgia.
体外数据表明，砷化合物可通过诱导T辅助淋巴细胞凋亡来抑制细胞介导的免疫。我们描述了两名急性早幼粒细胞白血病已缓解并接受三氧化二砷（ATO）巩固治疗的患者在治疗期间发生带状疱疹的情况。在这种并发症发生期间，他们的白细胞计数和分类均在正常范围内。我们的报告提示了ATO在体内的免疫抑制作用。两名患者对抗病毒口服药反应良好。临床医生在使用ATO治疗期间应注意这种并发症，因为早期抗病毒治疗可能有助于避免包括带状疱疹后神经痛在内的并发症。
