Balwierz Paweł, Grzeszczak Władysław
Klinika Chorób Wewnetrznych i Diabetologii, Slaskiej Akademii Medycznej, Zabrze.
Przegl Lek. 2003;60(9):565-70.
Hypertension belongs to the group of most frequent illnesses of the circulatory system; especially due to its spread and great effects. It is determined as one of the most important medical, social and economical problems. The purpose of these studies was to find answers to questions, if young men between the ages of 18-30 with family medical hypertension history have a difference in middle systolic, diastolic and mean blood pressure in comparison to an analogical group without familiar hypertension. The influence of blood pressure on central circulatory system, such as the heart was also evaluated--measurements of left atrium and ventricular thickness and LV mass were made. Analysis was made of velocities through left atrioventricular ostium and aortic ostium system searching for early indexes of systolic and diastolic left ventricular dysfunction. 24-hour blood pressure registration was made by means of ERKA machine with frequency three times a hour during daily activity (6 a.m.-10 p.m.) and one time a hour during the night (10 p.m.-6 a.m.), arranging in this way 57 time points (measuring points). From the midst of evaluated parameters, morphology of the left heart the major difference was caused in the thickness of left ventricular posterior wall (p < 0.03) and in the mass counted after Penn convention (p < 0.02) and mass index (p < 0.05) of the left ventricular heart. There was no differences in reality in systolic and diastolic functions of the left ventricular heart. Parameters of the systolic function (ejection fraction, fractional shortening, mean rate of circumferential shortening of left ventricle, aortal integration flow) were minimally better in the group with familiar hypertension medical history, and parameters of diastolic function (mitral flow--analysis of its ingredients) in the group without family hypertension medical history. A significant linear regression was obtained between: mean systolic pressure from daily activity, 24-hour mean systolic pressure of left ventricular mass in both groups but significantly was higher in the group with family hypertension.
高血压属于循环系统中最常见的疾病之一；尤其是因其广泛传播和巨大影响。它被确定为最重要的医学、社会和经济问题之一。这些研究的目的是寻找答案，即有家族性高血压病史的18至30岁年轻男性与无家族性高血压的类似组相比，其收缩中期、舒张期和平均血压是否存在差异。还评估了血压对心脏等中心循环系统的影响——测量了左心房和心室厚度以及左心室质量。通过分析左房室口和主动脉口系统的血流速度，寻找左心室收缩和舒张功能障碍的早期指标。使用ERKA机器进行24小时血压记录，在日常活动期间（上午6点至晚上10点）每小时测量3次，夜间（晚上10点至上午6点）每小时测量1次，这样共设置57个时间点（测量点）。在所评估的参数中，左心形态的主要差异在于左心室后壁厚度（p<0.03）、按照Penn惯例计算的左心室质量（p<0.02）以及左心室质量指数（p<0.05）。左心室的收缩和舒张功能在实际中并无差异。有家族性高血压病史组的收缩功能参数（射血分数、缩短分数、左心室圆周缩短平均速率、主动脉积分流量）略好一些，而无家族性高血压病史组的舒张功能参数（二尖瓣血流——对其成分的分析）略好一些。两组的日常活动平均收缩压与24小时左心室质量平均收缩压之间均获得显著线性回归，但有家族性高血压组的回归系数显著更高。
