Sonoda Yukio
Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Oncology (Williston Park). 2004 Mar;18(3):343-56; discussion 358, 361-2.
Epithelial ovarian cancer is the leading cause of death from gynecologic malignancies in the United States due, in large part, to the advanced stage at which it is commonly diagnosed. However, approximately one-third of cases are discovered at an early stage, when tumor is limited to the pelvis. Certain prognostic factors have been identified, which place patients with early disease at risk for recurrence and warrant the use of adjuvant therapy. Systemic chemotherapy remains the most commonly used adjuvant therapy in this setting, and several randomized European trials have recently suggested a benefit to its use. These studies, however, suffered from the lack of comprehensive staging, which must be considered when interpreting the literature on early-stage disease. Ideally, these patients should have access to a gynecologic oncologist prior to their initial surgical procedure.
上皮性卵巢癌是美国妇科恶性肿瘤死亡的主要原因，这在很大程度上是由于其通常在晚期才被诊断出来。然而，大约三分之一的病例是在早期被发现的，此时肿瘤局限于盆腔。已经确定了某些预后因素，这些因素使早期疾病患者有复发风险，并需要使用辅助治疗。在这种情况下，全身化疗仍然是最常用的辅助治疗方法，最近几项欧洲随机试验表明使用化疗有好处。然而，这些研究缺乏全面分期，在解释关于早期疾病的文献时必须考虑这一点。理想情况下，这些患者在初次手术前应能接触到妇科肿瘤学家。
