de la Cova Claire, Abril Mauricio, Bellosta Paola, Gallant Peter, Johnston Laura A
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, Room 704, New York, NY 10032, USA.
Cell. 2004 Apr 2;117(1):107-16. doi: 10.1016/s0092-8674(04)00214-4.
Experiments in both vertebrates and invertebrates have illustrated the competitive nature of growth and led to the idea that competition is a mechanism of regulating organ and tissue size. We have assessed competitive interactions between cells in a developing organ and examined their effect on its final size. We show that local expression of the Drosophila growth regulator dMyc, a homolog of the c-myc protooncogene, induces cell competition and leads to the death of nearby wild-type cells in developing wings. We demonstrate that cell competition is executed via induction of the proapoptotic gene hid and that both competition and hid function are required for the wing to reach an appropriate size when dMyc is expressed. Moreover, we provide evidence that reproducible wing size during normal development requires apoptosis. Modulating dmyc levels to create cell competition and hid-dependent cell death may be a mechanism used during normal development to control organ size.
在脊椎动物和无脊椎动物身上所做的实验都阐明了生长的竞争性本质，并催生了这样一种观点，即竞争是调节器官和组织大小的一种机制。我们评估了发育中器官内细胞之间的竞争性相互作用，并研究了其对器官最终大小的影响。我们发现，果蝇生长调节因子dMyc（原癌基因c-myc的同源物）的局部表达会引发细胞竞争，并导致发育中翅膀内附近野生型细胞死亡。我们证明，细胞竞争是通过诱导促凋亡基因hid来实现的，并且当dMyc表达时，竞争和hid功能对于翅膀达到合适大小都是必需的。此外，我们提供证据表明，正常发育过程中可重复的翅膀大小需要细胞凋亡。调节dmyc水平以引发细胞竞争和hid依赖性细胞死亡，可能是正常发育过程中用于控制器官大小的一种机制。
