Heidemann Steven R, Wirtz Denis
Department of Physiology, Michigan State University, East Lansing, MI 48824-3320, USA.
Trends Cell Biol. 2004 Apr;14(4):160-6. doi: 10.1016/j.tcb.2004.02.003.
Here we review studies of the physical, material properties of animal cells and their cytoskeleton, such as elastic stiffness and fluid viscosity, that determine how they respond to, and are shaped by, forces inside and out. Currently and historically, most such studies have reported a single value for a cell property and/or propose a single broad structural model based on nonliving materials. We believe that such physical studies would be of more interest to most cell biologists if greater emphasis were placed on the well-established regional differences within a cell and the ability of the cell to quickly change its mechanical behaviors
在此，我们回顾了关于动物细胞及其细胞骨架的物理和材料特性的研究，如弹性刚度和流体粘度，这些特性决定了它们如何响应内外力以及如何被这些力塑造。从当前和历史来看，大多数此类研究都报告了细胞特性的单一值，和/或基于无生命材料提出了单一的宽泛结构模型。我们认为，如果更加强调细胞内已确定的区域差异以及细胞快速改变其力学行为的能力，那么这类物理研究对大多数细胞生物学家来说会更有意义。
