甲苯在人肝脏、大脑和肺匀浆中的稳定性以及丙酮还原为2-丙醇的过程。

Stability of toluene and reduction of acetone to 2-propanol in homogenates of the human liver, brain and lungs.

作者信息

Buszewicz Grzegorz, Madro Roman

机构信息

Chair and Department of Forensic Medicine, Medical University of Lublin, ul. Jaczewskiego 8, Lublin 20-090, Poland.

出版信息

Forensic Sci Int. 2004 Apr 20;141(1):63-8. doi: 10.1016/j.forsciint.2003.12.011.

DOI:10.1016/j.forsciint.2003.12.011

PMID:15066716

Abstract

The homogenates of the livers, lungs and brains collected from five different cadavers were placed in the desiccator filled with vapours of rubber glue solvents and the concentrations of toluene, acetone and 2-propanol were determined during the 28-day storage at +25, +4 and -20 degrees C. It was demonstrated that only freezing of the material stabilised the initial concentration of these three xenobiotics while cooling to +4 degrees C resulted in limited conversion of acetone to 2-propanol and additionally reduced the biodegradation of toluene in the brain homogenates. Moreover, it was showed that at +25 degrees C the loss of acetone was almost equimolarly balanced by the 2-propanol increase, which allowed to estimate the initial concentration of acetone with the mean error of about 10%.

摘要

从五具不同尸体采集的肝脏、肺和脑匀浆被置于充满橡胶胶水溶剂蒸汽的干燥器中，并在25℃、4℃和 -20℃下储存28天期间测定甲苯、丙酮和2 - 丙醇的浓度。结果表明，只有将材料冷冻才能稳定这三种外源性物质的初始浓度，而冷却至4℃会导致丙酮有限地转化为2 - 丙醇，并额外降低脑匀浆中甲苯的生物降解。此外，结果显示在25℃时，丙酮的损失几乎与2 - 丙醇的增加等摩尔平衡，这使得能够以约10%的平均误差估算丙酮的初始浓度。