Kondo Yasuko, Hollingsworth Emporia F, Kondo Seiji
Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Int J Oncol. 2004 May;24(5):1101-9.
With tendency to invade rapidly in the brain, malignant gliomas are very resistant to conventional therapies including radiation and chemotherapy. Recent advances in genetic and molecular techniques have made it possible to define characteristic molecular profiles of malignant gliomas. Based on the list of the molecules closely related to glioblastoma tissues, we reviewed strategies targeting them. Target molecules extensively studied include EGFR, PTEN, telomerase and signal pathway modulators for Ras/Raf/MAPK and PI3K/Akt/mTOR pathways. Therapies targeting specific molecules may result in killing tumor cells effectively while keeping normal cells intact.
恶性胶质瘤倾向于在大脑中迅速侵袭，对包括放疗和化疗在内的传统疗法具有很强的抗性。基因和分子技术的最新进展使得定义恶性胶质瘤的特征性分子图谱成为可能。基于与胶质母细胞瘤组织密切相关的分子列表，我们综述了针对这些分子的策略。广泛研究的靶分子包括表皮生长因子受体（EGFR）、第10号染色体同源丢失性磷酸酶-张力蛋白基因（PTEN）、端粒酶以及Ras/Raf/丝裂原活化蛋白激酶（MAPK）和磷脂酰肌醇-3激酶（PI3K）/蛋白激酶B（Akt）/哺乳动物雷帕霉素靶蛋白（mTOR）信号通路的调节剂。针对特定分子的疗法可能在保持正常细胞完好无损的同时有效杀死肿瘤细胞。
