Theetranont C, Vanittanakom P, Gropp A
Department of Pathology, Faculty of Medicine, Chiang Mai University, Thailand.
J Med Assoc Thai. 1992 Mar;75(3):157-62.
Cholinesterase (ChE) activity in the chondrocranium of normal and exencephalic trisomy 12 mouse fetuses was studied. Non-specific cholinesterase activity was found strongly in the developing bone cells at the central zone and weakly in the more maturely developed bone cells at the peripheral zone of the chondrocranium of both normal and exencephalic trisomy 12 mouse fetuses. In exencephalic mouse fetuses, the ChE-activity was lesser than in the normal ones which corresponded to hypoplastic chondrocranium. The centrifugal direction of the maturity of individual bone cells could be demonstrated by the activity of cholinesterase. The young bone cells showed strong ChE-activity while the more matured cells showed weak ChE-activity. The enzyme activity disappeared when the definite tissue structure was well developed. From this study, it may be concluded that ChE plays a role in chondrocranium development which is different from its known function in the adult tissue.
研究了正常和无脑儿12三体小鼠胎儿软骨颅中的胆碱酯酶（ChE）活性。在正常和无脑儿12三体小鼠胎儿软骨颅的中央区，发育中的骨细胞中发现了强烈的非特异性胆碱酯酶活性，而在周边区发育更成熟的骨细胞中活性较弱。在无脑儿小鼠胎儿中，ChE活性低于正常小鼠，这与软骨颅发育不全相对应。胆碱酯酶的活性可以证明单个骨细胞成熟的离心方向。年轻的骨细胞显示出强烈的ChE活性，而成熟度更高的细胞显示出较弱的ChE活性。当确定的组织结构发育良好时，酶活性消失。从这项研究中可以得出结论，ChE在软骨颅发育中发挥的作用与其在成体组织中的已知功能不同。
